i went on zoloft during my 2nd trimester due to horrible anxiety during my pregnancy. the difference it made has been amazing. it was a hard choice, but my doctor, husband and myself all agreed that the risks of such severe and debilitating anxiety greatly outweighed the risk of the zoloft. our baby is perfect and had no side effects at birth or since. we are getting ready to try for #2 and although i wish i didn't have to take anything while pregnant, i am terrified of experiencing such anxiety again, so i will stay on it. good luck :)