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05-09-2012 at 10:50 AM
musicalsil...
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Have you heard of myo-inositol for PCOS?

Since my PCOS diagnosis, I've been going crazy doing internet research. My most recent find has me seriously intrigued, and I was wondering if anyone had tried it/heard of it - myo-inositol.

It's in the B vitamin family, and appears to have very similar effects to metformin, but without the nasty GI side-effects. There have been a number of randomized clinical trials that have been performed that show it works to induce ovulation/regular cycles/nicer quality eggs in women with PCOS. This blog is a year old, but it sites a number of useful studies on the topic.

The most recent article that turned me on to this is found here

Hopefully my html linking skills worked there ... if not, I'll come back and fix it.

Obviously I won't go dosing myself with this stuff until I do some more research and talk to my RE (and convince my husband I'm not nuts about this), but I was wondering what people thought of this, and wanted to share this information for other PCOSers it might help!!

I also have pdfs of a review of the RCTs that've been done and the trial comparing myo-inositol to metformin if anyone is interested - PM me and I can email it to you or something!
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05-09-2012 at 10:56 AM
sophie206
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I haven't--but I am going to check out your links when I have time to read it. Thanks for sharing!
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05-09-2012 at 10:57 AM
Suz+Mo
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Very interesting research!! Good job musical!  I'm PMing you with my email so I can see the PDF.

It's worth mentioning to my RE just to see if it might be a good option for me!

Dx: PCOS & Type 3 Von Willebrand's Disease
Jan 2012- Clomid 50mg- non-responsive
April 2012- Clomid 100mg- non-responsive
May 2012- Clomid 150mg & Metformin
BFP on June 18, 2012~ EDD Feb. 27, 2013, Beta #1- 92, Beta #2- 232

I go by "SuMo" in chat! Love the chat ladies!!!!
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05-09-2012 at 11:02 AM
keelyd
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Thanks!  You find the best stuff!

TTC #1 since August 2011
March 2012: Dx - atypical PCOS (high LH, anovulation, amenorrhea) | Prescribed Clomid+trigger+TI - opted to wait out for one (92 day) cycle
May 2012: Started Acupuncture +TCM
June/July 2012: SA #1 = 3.9M total count, 3% motile, morph unclear | Treatment Cycle #1 - 100 mg Clomid no response; CD17-21: 5mg Femara (18.5mm & 23 mm follies); CD26: IUI (post-wash count=100k :[ ) = BFN
Aug 2012: HSG = all clear; consult w/ RE = IVF recommendation due to extreme MFI

 
05-09-2012 at 11:05 AM
beth9409
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I just sent you a PM. I haven't heard of it before. My sister has PCOS and has problems taking metformin.
TTC#1 since 5/2011
DX: PCOS (8/13/12), Myasthenia Gravis (2002), Aplastic Anemia (2005), one copy MTHFR
DH SA: count 52% motility (slow progressive), 0% normal morph
June-July 2012: Clomid cycles=BFNs
August 2012: New RE, Metformin 850mg (ramp up to 1700mg)
Letrozole 7.5mg+Vivelle+TI+Progesterone=BFN Lining 5.1mm
Sept. 2012: Started Metformin 1700mg IUI#1: Letrozole 7.5mg+Vivelle+Premarin+IUI+Progesterone=BFN Lining 5.1mm, 3.6mil post wash
Oct. 2012: IUI#2 Letrozole 7.5mg+Dexamethasone+Vivelle+Progesterone=BFN
Nov '12-March '13 on a break
April 2013: IUI#3 Letrozole 7.5mg+Dexamethasone+Vivelle+Progesterone=BFN
June 2013: IVF#1

~PAIF/SAIF Welcome~  
05-09-2012 at 12:23 PM
musicalsil...
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Suz+Mo:

Very interesting research!! Good job musical!  I'm PMing you with my email so I can see the PDF.

It's worth mentioning to my RE just to see if it might be a good option for me!

Sent you an email! I'd be very interested to hear what your RE says about it. I don't have an awesome rapport with mine, so I'm almost hesitant to bring it up, so it could help knowing what another RE thinks of it first!
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TTC#1 with atypical/lean PCOS - BFP after 14 months!
My BFP Chart

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05-09-2012 at 12:25 PM
musicalsil...
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musicalsilver is not online. Last active: 05-22-2013, 12:33 PMSilver
beth9409:
I just sent you a PM. I haven't heard of it before. My sister has PCOS and has problems taking metformin.
Sent you an email! I hope it can help your sister - the reports I've read so far show no side-effects (which is quite remarkable in the scheme of pharmaceuticals these days!)!
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TTC#1 with atypical/lean PCOS - BFP after 14 months!
My BFP Chart

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BabyFetus Ticker

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05-09-2012 at 12:26 PM
musicalsil...
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musicalsilver is not online. Last active: 05-22-2013, 12:33 PMSilver
keelyd:
Thanks!  You find the best stuff!
*blushes* Aww, thanks. Being in research in the sciences has some benefits - along with a need to research things exhaustively, access to papers through my university is one of them!
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TTC#1 with atypical/lean PCOS - BFP after 14 months!
My BFP Chart

Photobucket

BabyFetus Ticker

Anniversary 
06-21-2012 at 2:49 PM
kecobrown
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kecobrown is not online. Last active: 06-21-2012, 2:49 PMNewbie
hi yes i have heard of inositol for PCOS. I was like many searching clicking and trying to find remedies for pcos. I went to the doctor but the meds they gave seemed to make the problem worse. perhaps i needed to wait longer. However I was going for something natural. I have been taking inositol for 3 months and also combining Choline. I hadnt had a period in over six months. I had my first cycle last month. the inositol improved my high cholesterol-or shall I say made it normal, my blood pressure is good. I am on a diet but Im able to loose the weight I love inositol. It is a ,life saver
 
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