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11-05-2012 at 3:03 PM
Julie21613
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Mrs. McIrish!

I was ready a post on IFV and saw your response.  I also saw in your siggy that you transferred "3 crappy" embyros.  What's up with that?  I have seen many have BFP's transferring 4 cells on 3dt.  So I'm not giving up hope for you!  FX they decide to stick around.

 Hugs.

Me 31, DH 32 TTC summer 2008 Diagnose me. DOR, DH perfect IUI # 1 6/2010, BFN IUI # 2 8/2010, BFN IVF # 1 10/2010 Canceled poor response IVF 1.2 12/2010 BFP! mc 6 weeks 2 days Mental health break for 10 months IVF # 2 10/2011 BFN IVF # 3 5/2012 BFP! 10 eggs retrieved (best ever) 7 fertilized transferred 3 Beta #1 14dpo - 72, Beta #2 17dpo 145 Beta 3 20dpo 521 First u/s June 15 saw HB 126 bpm missed m/c 7/5/12 10 weeks D&C 7/6/12 IVF#4 ER 9/30 ET 10/3 Beta 10/16 BFFN. IVF #5 final with o/e. ER 1/21 only 1 retrieved, hoping my lonestar is the one. Beta #1 2/6/13 = 209.... please let this be it! Keep growing lonestar! Beta #2 2/8/13 - 586! , Beta #3 2/10/13 = 1898. First u/s perfect little heart beat at 116 bpm. Measure 6 weeks 1 day. EDD 10/14/13 3/4/13 measuring right on track beautiful heartbeat 171 bpm, graduated from RE to OB... bittersweet. PAIF/SAIF always welcome!  
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11-05-2012 at 3:14 PM
Mrs.McIris...
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Mrs.McIrish is not online. Last active: 05-19-2013, 9:48 AMGold

Yeah, sadly our ET was a disaster even with donor eggs.. Story of my IF life..  We had 5 embryos left (1 arrested from day 3 to 5) but of the 5, 4 were still morulas and 1 was an early blast, a 1CC. I was shocked at the poor quality since it was just supposed to be my crappy eggs as our problem so how could this happen? It was devastating to say the least. We put back the 1CC, a 3M morula and a 1M morula. It would be a miracle for this to work...     the other 2 morulas were kept in culture to day 6 to see if they were just slow growers but nothing was able to be frozen.

My DH has always had great SA's but I've learned from others that the sperm can still have fragmented DNA which will cause the embryos to fail from day 3 to 5. I'm suspecting that might be the problem. DH has a lot of the risk factors for it so I'm gathering info to order that test. It's experimental and lots of REs don't believe in it.  You also can't really fix if it comes back poor. You can try some vitamins to improve it but it's basically a crap shoot for the embryologist to blindly pick a good sperm to ICSI with.  I'm not sure I can take anymore of this...

TTC #1 since 8/1/10; Me:39 and BRCA1+, DH:45
DOR (FSH 24.3)/ terrible egg quality
5 IUI's: 2/11 to 6/11 and 1/12= BFN
OE IVF#1-4 8/11-6/12= all BFN
DE IVF#5 11/12 bad embryos= BFFN
FINAL DE IVF #6 1/13: cancelled as second donor backed out during stims
Was added last minute as 3rd recipient to new donor on 1/18; ET1/23/13
2/1/13 BFP for the first time ever; Beta hell for several weeks: miscarriage 7 wks
CFNBC ...Me &You, Just Us Two...
GradyPhotobucket
Riley
RIP Riley 1/4/12
PAIF/SAIF Welcome  
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11-05-2012 at 3:28 PM
Sophistiki...
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McIrish, just wanted to say that I am so sorry you are going through this.... Thinking about you. (((Hugs)))
TTC #1
Dx = AMA/DOR, hypothyroid, submucosal fibroid, adenomyosis, mild MFI
IUI#1-3 = BFN
IVF #1 (EPP Antagonist); 3R, 2M, 1F; 3dt of one 12-cell embryo = BFN
IVF #2 (EPP MDLF); 6R, 4M, 3F; 3dt of 1-7 cell, 1-8 cell & 1-10 cell = BFP; confirmed C/P @ 4w2d
Genetic carrier screening negative (CF, Fragile X, SMA, Tay Sachs)
Karyotyping, autoimmune & thrombophilia panels all normal
IVF#3 (DE); 13R, 12M, 8F; 5dt of two “excellent quality” blasts = BFP
Beta#1 = 203, Beta #2 = 81, Beta #3 = 17; confirmed C/P @ 5w1d
Two frosties left
*PAIF/SAIF welcome*  
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11-05-2012 at 3:42 PM
MandaS08
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MandaS08 is not online. Last active: 05-19-2013, 1:06 PMSilver

Did you do ICSI this round?

I'm really sorry to hear this-but I've still got everything crossed for you!!!

TTC since 5/2010
DX with Diminished Ovarian Reserve
AMH of 1.1 - 7/2011; AMH of .29 7/2012; AMH of .42 8/2012
BFP 9/1/10-M/C confirmed 9/8/10-Methotrexate 10/6/10
IUI #1 (w/clomid)-9/5/11-BFN
IUI #2 (w/clomid)-10/5/11 - BFP
11/1/12-No sac seen; 11/2/11 and 11/9/11-Methotrexate
IVF #1- ER 2/2; ET 2/5; Two 8 cell embryos transfered Beta 2/16 = 5 = BFFN
Surprise BFP - 5/7/12
U/S on 6/8/12 - H/B at 128 BPM; U/S on 6/14/12 @ 9wks-No H/B-D&C on 6/17/12
Baby Bean-We miss you
IVF 2.0- ER 10/17; ET 10/20
One 12 cell, one 10 cell and one 8 cell embryo transfered
BFP! Beta #1 650; Beta #2 1200; Beta #3 5700
11/16/12 U/S- Two nuggets with perfect heartbeats! BabyFruit Ticker
My Blog- http://waitingonaangel.wordpress.com/
 
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11-05-2012 at 4:01 PM
Km672
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Km672 is not online. Last active: 05-16-2013, 8:29 PMNewbie
I was so sad to read this!! Please know we are pulling for you! I hope you never have to deal with the sperm fragmentation testing, but I've been through it if you have any questions.
Me (31) DOR/ MH (34) azoo/high DFI TTC#1 since 2009 IVF #1 cancelled dt poor response/ IVF #2 & #3: BFFN/ Natural Surprise BFP, early m/c -endometrial bx & methotrexate administered/ IVF#4:nothing to transfer/ DS IUI#1 BFN/ DS IUI#2 BFN/ IVF#5 (1st w/ DS):another BFFN/ Currently planning on DE and DS cycle Summer 2013. This has to be it- 
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11-05-2012 at 4:09 PM
stinkerbel...
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stinkerbell6879 is not online. Last active: 05-17-2013, 9:10 PMBronze
(((HUGS))) and I am going to cross my fingers for you!


Me:33(Dx Turners Syn) DH: 34(Perfectly Fine!) ~DE Cycle Set to start APRIL 2013!!~ 
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11-05-2012 at 6:16 PM
Mrs.McIris...
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Mrs.McIrish is not online. Last active: 05-19-2013, 9:48 AMGold
MandaS08:

Did you do ICSI this round?

I'm really sorry to hear this-but I've still got everything crossed for you!!!

yes,  we did ICSI. Fertilization is not our problem. The embies were good on day 3 and crap on day 5.  

TTC #1 since 8/1/10; Me:39 and BRCA1+, DH:45
DOR (FSH 24.3)/ terrible egg quality
5 IUI's: 2/11 to 6/11 and 1/12= BFN
OE IVF#1-4 8/11-6/12= all BFN
DE IVF#5 11/12 bad embryos= BFFN
FINAL DE IVF #6 1/13: cancelled as second donor backed out during stims
Was added last minute as 3rd recipient to new donor on 1/18; ET1/23/13
2/1/13 BFP for the first time ever; Beta hell for several weeks: miscarriage 7 wks
CFNBC ...Me &You, Just Us Two...
GradyPhotobucket
Riley
RIP Riley 1/4/12
PAIF/SAIF Welcome  
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11-05-2012 at 6:53 PM
pinkmickey...
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Sudlersville
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pinkmickey24 is not online. Last active: 05-19-2013, 10:20 AMSilver
Mrs.McIrish:

Yeah, sadly our ET was a disaster even with donor eggs.. Story of my IF life..  We had 5 embryos left (1 arrested from day 3 to 5) but of the 5, 4 were still morulas and 1 was an early blast, a 1CC. I was shocked at the poor quality since it was just supposed to be my crappy eggs as our problem so how could this happen? It was devastating to say the least. We put back the 1CC, a 3M morula and a 1M morula. It would be a miracle for this to work...     the other 2 morulas were kept in culture to day 6 to see if they were just slow growers but nothing was able to be frozen.

My DH has always had great SA's but I've learned from others that the sperm can still have fragmented DNA which will cause the embryos to fail from day 3 to 5. I'm suspecting that might be the problem. DH has a lot of the risk factors for it so I'm gathering info to order that test. It's experimental and lots of REs don't believe in it.  You also can't really fix if it comes back poor. You can try some vitamins to improve it but it's basically a crap shoot for the embryologist to blindly pick a good sperm to ICSI with.  I'm not sure I can take anymore of this...

 

***Ticker Warning***

 

 

Mrs. McIrish I hope you don't mind me posting here but I was reading this post and wanted to mention a fairly new procdure called PICSI. My DH's numbers have steadily decreased since his first SA and at each IVF cycle they dwindled further. Our first two cycles were failures because our embryos arrested early or developed poorly. On this last cycle my RE mentioned PICSI which mimics the fluid that surrounds the egg that the sperm have to get through in order to fertilize it and this allows the embriologist to pick the healthiest sperm out of the sample to inject for ICSI. That resulted in our 6 fertilized eggs growing to day 5 and giving us two blastocysts. I don't know if this is something your RE does and if it is something that would help, but I just thought it was worth metioning. Again I truly hope you don't mind that I posted this hear and I am wishing you the very best with this cycle.

~TTC since July 2010~
CD3 Bloodwork:Normal
HSG-Clear
SA:Low Morph
IVF with ICSI #1: ER 12/16 (4 ER/3 Mature/0 Fertilized)
IVF with ICSI #2: ER 5/17 (4 ER/4 Mature/3 Fertilized)/ET 5/20 (2 embryos transferred)-BFN
IVF with PICSI #3: ER 9/8 (11 ER/8 Mature/7 Fertilized)/ET 9/13 (2 AA blastocysts transferred)
Beta#1, 9/26: 719 Beta#2, 9/28: 1,436 Beta#3, 10/1: 3,446


Lilypie Pregnancy tickers 
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11-05-2012 at 7:16 PM
Mrs.McIris...
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Mrs.McIrish is not online. Last active: 05-19-2013, 9:48 AMGold
pinkmickey24:
Mrs.McIrish:

Yeah, sadly our ET was a disaster even with donor eggs.. Story of my IF life..  We had 5 embryos left (1 arrested from day 3 to 5) but of the 5, 4 were still morulas and 1 was an early blast, a 1CC. I was shocked at the poor quality since it was just supposed to be my crappy eggs as our problem so how could this happen? It was devastating to say the least. We put back the 1CC, a 3M morula and a 1M morula. It would be a miracle for this to work...     the other 2 morulas were kept in culture to day 6 to see if they were just slow growers but nothing was able to be frozen.

My DH has always had great SA's but I've learned from others that the sperm can still have fragmented DNA which will cause the embryos to fail from day 3 to 5. I'm suspecting that might be the problem. DH has a lot of the risk factors for it so I'm gathering info to order that test. It's experimental and lots of REs don't believe in it.  You also can't really fix if it comes back poor. You can try some vitamins to improve it but it's basically a crap shoot for the embryologist to blindly pick a good sperm to ICSI with.  I'm not sure I can take anymore of this...

 

***Ticker Warning***

 

 

Mrs. McIrish I hope you don't mind me posting here but I was reading this post and wanted to mention a fairly new procdure called PICSI. My DH's numbers have steadily decreased since his first SA and at each IVF cycle they dwindled further. Our first two cycles were failures because our embryos arrested early or developed poorly. On this last cycle my RE mentioned PICSI which mimics the fluid that surrounds the egg that the sperm have to get through in order to fertilize it and this allows the embriologist to pick the healthiest sperm out of the sample to inject for ICSI. That resulted in our 6 fertilized eggs growing to day 5 and giving us two blastocysts. I don't know if this is something your RE does and if it is something that would help, but I just thought it was worth metioning. Again I truly hope you don't mind that I posted this hear and I am wishing you the very best with this cycle.

thanks. I don't mind the advice or you posting here. I appreciate it. I have heard of picsi but don't know if my donor clinic does it. It isn't on the list of "services" but I will look more into it. We are going to get the frag test first to see what it shows. Thx again. 

TTC #1 since 8/1/10; Me:39 and BRCA1+, DH:45
DOR (FSH 24.3)/ terrible egg quality
5 IUI's: 2/11 to 6/11 and 1/12= BFN
OE IVF#1-4 8/11-6/12= all BFN
DE IVF#5 11/12 bad embryos= BFFN
FINAL DE IVF #6 1/13: cancelled as second donor backed out during stims
Was added last minute as 3rd recipient to new donor on 1/18; ET1/23/13
2/1/13 BFP for the first time ever; Beta hell for several weeks: miscarriage 7 wks
CFNBC ...Me &You, Just Us Two...
GradyPhotobucket
Riley
RIP Riley 1/4/12
PAIF/SAIF Welcome  
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11-05-2012 at 7:52 PM
Julie21613
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Julie21613 is not online. Last active: 05-18-2013, 7:52 PMBronze
I'm so very sorry to hear this......I'm praying for your "miracle".   Was your donor a proven donor or was this her first donor cycle?    I wish there was something I could say to you to make you feel better.  FX that you get the surprise of you lives.
Me 31, DH 32 TTC summer 2008 Diagnose me. DOR, DH perfect IUI # 1 6/2010, BFN IUI # 2 8/2010, BFN IVF # 1 10/2010 Canceled poor response IVF 1.2 12/2010 BFP! mc 6 weeks 2 days Mental health break for 10 months IVF # 2 10/2011 BFN IVF # 3 5/2012 BFP! 10 eggs retrieved (best ever) 7 fertilized transferred 3 Beta #1 14dpo - 72, Beta #2 17dpo 145 Beta 3 20dpo 521 First u/s June 15 saw HB 126 bpm missed m/c 7/5/12 10 weeks D&C 7/6/12 IVF#4 ER 9/30 ET 10/3 Beta 10/16 BFFN. IVF #5 final with o/e. ER 1/21 only 1 retrieved, hoping my lonestar is the one. Beta #1 2/6/13 = 209.... please let this be it! Keep growing lonestar! Beta #2 2/8/13 - 586! , Beta #3 2/10/13 = 1898. First u/s perfect little heart beat at 116 bpm. Measure 6 weeks 1 day. EDD 10/14/13 3/4/13 measuring right on track beautiful heartbeat 171 bpm, graduated from RE to OB... bittersweet. PAIF/SAIF always welcome!  
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11-06-2012 at 9:55 AM
PurpleIris...
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God, I'm so sorry.  This absolutely sucks, sucks, sucks.  You're not out yet, and I'm going to send every positive vibe I have your way.  But I am sorry for the disappointment and the apparent sperm issues.  This isn't fair. :(
Married 8/2008. IVF with PGD March 2013.
3/22 ER: 25R, 20M, 15F. 9 genetically normal, and 3 survived to Day 5
3/27 ET: transferred 1 embryo, beta 9dp5dt=163, 12dp5dt=639
4/25 1st ultrasound at 7 weeks = identical twins with heartbeats?!
 
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11-06-2012 at 10:30 AM
BzeetyD
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BzeetyD is not online. Last active: 05-18-2013, 5:10 PMSilver

I'm sorry about this. Very sorry and I know that the word "disappointed" doesn't even begin to describe how you feel.

 
BzeetyD = 37, Mr. BzeetyD = 43 together 12/02 married 9/08
TTC #1 since 1/10
DX: Unexplained/MFI issues
Long story: trying on our own + testing testing testing with 6 rounds of Clomid , more testing, injectables + TI, laparoscopy - one tube blocked, 2 IUIs with Follistim...BFNs.
RPL testing all normal

Moving on to IVF.

Our lil' lost sparks:
5w3d loss 7/30/10 - EDD March 2011
8w loss 4/15/11 - EDD November 2011
8w3d loss 8/2/12 - EDD March 2012
4w c/p loss 10/29/12 - EDD July 2012

IVF #1 April 2012 = BFN, IVF #2 June 2012 = BFP. U/S 7/23 = saw heartbeat but measuring behind. Follow up U/S on 7/30 - no heartbeat. D&C 8/2. Trisomy 12. IVF #3 Oct 2012 = Chemical Pregnancy

Phone consult with CCRM on 12/12/12 - ODWU 1/4/13 - both tubes clear(!) - AFC 24, AMH 3.2, FSH 9.6, LH 5.4, E2 25. DH has high frag rate but improved!
IVF #4 March 2013 CCRM. EP protocol w/ Menopur, Gonal-F & Dexamethasone. ER 3/29 & IMSI, PICSI. 43R 13M 10F 6blasts bio'd. CCS testing reveals 3 normals!!! FET 5/31/13



"I'm not telling you it's going to be easy, I'm telling you it's going to be worth it."

Everybody is welcome!!!  
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