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11-15-2012 at 11:43 PM
chucktgirl
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chucktgirl is not online. Last active: 04-18-2013, 4:43 PMBronze

Results from my WTF are in. Crap.

I had my WTF appt with my RE Tuesday. Still reeling from it. He thinks it is not likely I will get a take-home-baby. He said my chances are about 2% if I do another round of IVF, and he's not sure if it's worth it emotionally or financially. He said he will do another round if I want to, of course, but he doesn't want to get my hopes up. Basically, the fault seems to be my old eggs. My stimming results were "superb" (now my FAVORITE phrase:) for my age. He was happy with the fertilization. But all that were PGD tested came back severely abnormal, so they transferred none. My RE's recommendation is wait until January (I don't want to wait that long, but it seems EVERY RE closes at the end of Dec) and do another IVF round. He wants to take all fertilized embryos and transfer them in (up to SIX!) on day three, with no PGD testing at all. He wants to hope for the best. I am so conflicted. I want to hope for the best, too, but I also don't want to deal with the possiblility of getting a positive and carrying an embryo that is only going to make it several weeks before m/c. I am out of time. I really don't know what to do. We were supposed to call back with a decision ASAP, and we still can't decide. So, the million dollar question is, do we:
A) Try another round of IVF and (hopefully) transfer whatever we can get on day 3. Pro is that one of them might actually stick. Cons are that it might be a genetically doomed one that sticks, which could leave me with another m/c, dnc, and out of time to try again. (I'm only going to try until Feb.)
B) Try another round of IVF and hope I have some fertilized embryos that stick around until day 5 AND test as genetically normal (at an additional OOP fee of $3500) and hope they stick. RE says that 10% of PGD embryos have bad results, so they could be putting in bad embryos to begin with, OR they could be discarding GOOD ones!

I am so sick and tired of trying to do the math on infertility. I'm exhausted, confused, devastated, and am feeling emotions I don't even have words for. Please tell me what you would do with these perameters!

My (old) BLOG: www.ivfbabyquest.wordpress.com
TTC since Jan 2010 with OPKs. Me: 41, Hypothyroidism, hetero MTHFR C677T, hetero Factor V Leiden (no previous clots) Dx: DOR due to AMA. Rx: 100mg Levothyroxin, FaBB tab, Spring Valley Prenatal Vitamins, Vitamin D. Hubby: 34, Hyperthyroidism, Fragile X carrier, Great swimmers!
Natural PG 9/27/11; MC at 8wks. Used Cytotec to expel: 1/20/12 (unpleasant)
First RE visit: 8/8/12, Saline Sonogram: 8/28/12(4cm unknown mass in upper left of uterus) 2nd Saline Sonogram: 10/2/12 (mass disappeared!) IVF injection class: 10/11/12
IVF #1: 10/17/12 Baseline: FSH- 9.4, E2- 24, LH- 3.7, Progesterone- 0.3. 6 follicles in my right ovary & 9 in my left. Rx: 150 Bravelle & 150 Menopur SQ in AM. 10/21/12: Add Ganirelix SQ in PM. 10/26/12: hCG Trigger IM. ER 10/28/12: 13R, 7M, 6F. 5 Made it to PGS. ET 11/2/12: CANCELED. PGS: All 5 have "severe abnormalities." Devastated. Begged RE for back-to-back IVFs; Started Provera 11/2/12. AF said FU and came anyway, destroying any chance for a Dec IVF. Maxed out lifetime IF meds insurance. I can barely breathe, waiting to get through this process, hoping for my take-home-baby.
IVF #2: 1/7/13 Baseline: FSH- 8.8, 4 follicles in my right ovary & 6 in my left. Rx: 150 Bravelle & 150 Menopur SQ in PM. 1/11/13: Add Ganirelix SQ in AM. 1/16/13: hCG Trigger IM. ER 1/18/13: 9R, 5M, 5F. 2 Made it to PGS. ET 1/23/13: CANCELED. PGS: All embryos have "multiple severe abnormalities." RE recommends we stop trying and focus on living childless, due to the repeated extremely poor quality of my eggs. I don't even know what to do with that.
IVF #3- NEW RE! 100% OOP: 3/1/13 Baseline: FSH- 9.6, E2- 61, Progesterone- 0.94, 3 follicles in my right ovary & 4 in my left. Rx: 150 Bravelle & 150 Menopur SQ in PM. 3/7/13: Add Ganirelix SQ in AM. hCG Trigger 3/9/13 SQ. 3/11/13 ER: 6R, 2M, 2F. Day 3: one 8 cell, grade 0. 3/16/13 Five day ET: one early blast, grade Fair. 3/24/13 Started period a day before beta. BFN.
IVF #4 (FINAL) (Added acupuncture to this cycle.): 3/25/13 WTF & Baseline: FSH-11.8, E2- 56, Progesterone- 0.84 3/26/13 Start stims. 3/30/13 u/s: 5 follicles in my right ovary & 4 in my left. Rx: 225 Bravelle & 225 Menopur SQ in PM. 3/31/13 Add Ganirelix SQ in AM. hCG Trigger 4/3/13 SQ. 4/5/13 ER: 5R, 3M, 3F naturally. Day 3: two 8 cell, grade 0, one 8 cell, grade 2 (Scale 0-best to 3-worst). 4/10/13 Five day ET: two blastocysts (the 3rd stopped growing.) 4/18/13 Beta: 2.5 BFFN.
No DE or adoption for us, FIRM.
That’s it for us. I am beyond devastated and have no idea how to proceed from here. My life has been forever altered by this experience. Best wishes to all in their journeys! 
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11-16-2012 at 7:17 AM
MrsGlitter...
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I see we live in the same state! I'm so sorry that your head is spinning- that is a lot of information and a lot of money.

Have you gotten a second opinion? I think that's what I'd do if I were in your situation.

TTC since October 2008My Infertility History is listed in my Blog
My Blog
BabyFruit Ticker 
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11-16-2012 at 7:23 AM
hootie123
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I would also consider getting a second opinion on your situation.  Are you not going to consider donor eggs yet? 


TTC #1 since 6/09
Dx: PCOS and MFI
3 IUIs, 4 IVFs = BFFN
IVF #5/FET = ??
P/SAIFW 
 
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11-16-2012 at 8:06 AM
BAKERMOMHD...
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chucktgirl:
B) Try another round of IVF and hope I have some fertilized embryos that stick around until day 5 AND test as genetically normal (at an additional OOP fee of $3500) and hope they stick. RE says that 10% of PGD embryos have bad results, so they could be putting in bad embryos to begin with, OR they could be discarding GOOD ones!

!

This is what we just tried for IVF#3.  Our embies have NEVER made it to day 5.  We switched RE's / switched protocols and clinics this round (#3) and we have ONE (over the moon excited) ONE beautiful top quality blast out of 14 fertilized.  The blast was biopsied yesterday and we should have the PGD results next week.  It is expensive (2500$), but knowing if that blasty is chromosomally normal with a 95% confidence before transfer..is priceless to us. If you go this route also consider : you'll be doing a FET (no fresh transfer) and the freeze / thaw / biopsy processes can cause nominal damage.  When I spoke with the embryologist yesterday, she indicated with top quality day 5 embryo's the risk with freeze / thaw / biopsy is about a 7% loss.

No guarantee this will be our take home baby, but we definitely are feeling more optimistic :)

Good luck to you!!!

Me = 39 DH = 50 TTC (since 01/2009 after a short break, I stopped counting *cycles* in 2010) DX 2010 : Unknown Infertility , AMA HSG 2005 = Normal / HSG 2010 = Normal SA 2005 = Normal / SA 2010 /2012 = Slightly low count : motility, morphology GREAT! Chromosomal analysis, MTHFR, ANA's, Lupus, Protein C, Protein S, APCR = Normal 2011
M/C : 2005 (7wk), 2010 (6wk), 2011 (7wk)
8 IUI's 2010-2011 all BFN
IVF/ICSI antagonist 01/2012 #1 = BFN
IVF/ICSI antagonist long 06/2012 #2 = BFN
IVF/ICSI/CGH MDLF New Clinic/New RE 11/2012 #3 = One beautiful boy blasty frozen PGS normal
IVF/ICSI/CGH MDLF 02/2013 #4 = One more beautiful boy blasty frozen PGS normal
SAIF / PAIF always welcome ****
 
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11-16-2012 at 8:08 AM
DoublePort...
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I have no advice that wasn't mentioned by PPs but wanted to send you huge ((hugs)). One of the worst aspects of IF is that there never seems to be an option that is clear cut.
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Me: 29 ~ Stage IV Endo ~ AMH .38 ~ AFC 8
AMH .97 as of 4/2012!
Him: 27 ~ perfect swimmers
Laparotomy with partial oophorectomy 8/2009 to remove cysts/endo. Stopped BC 4/2010.
Multiple clomid rounds from 11/2010 to 6/2011. ~ All BFN
IUI w/clomid 7/2011. IUI w/clomid & injectables 11/2011 & 1/2012. ~ All BFN
Occasionally using acupuncture.
IVF #1:EPP 5/2012 ~ (4R, 3M, 2F w/ICSI). Both embies txfrd. ~ BFN
BCP to manage Endo from 10/2012 to 12/2012.
PAIF/SAIF always welcome!

If you're wondering about my avatar...it's a fried pickle chip shaped like a fetus! 
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11-16-2012 at 8:13 AM
Km672
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I am so sorry you are dealing with this!

Personally, I don't think I could go through with blindly putting back multiple embryos and have a big risk of miscarrying. I don't know why your RE is saying PGD has a 10 percent error rate, I have done PGD for 3 cycles and was told it was much more accurate.

Why do they need your decision so quickly? As you know, this is a big, expensive, emotional ordeal and your answer may be more clear after you and your husband have time to process.
Me (31) DOR/ MH (34) azoo/high DFI TTC#1 since 2009 IVF #1 cancelled dt poor response/ IVF #2 & #3: BFFN/ Natural Surprise BFP, early m/c -endometrial bx & methotrexate administered/ IVF#4:nothing to transfer/ DS IUI#1 BFN/ DS IUI#2 BFN/ IVF#5 (1st w/ DS):another BFFN/ Currently planning on DE and DS cycle Summer 2013. This has to be it- 
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11-16-2012 at 8:57 AM
maggie2324
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If you are going to cycle either way, I would do it without PGD. The thing is, some viable embryos don't make it to day 5 in the lab, so not only are you risking PGD errors, damaging by biopsy, but you're also risking embryos dying on their own.

While you are risking a potential inevitable miscarriage if an abnormal embryo implants, I think it also gives you the best chance for a normal, healthy embryo to implant as well.  
Photobucket   
Me (24) DH (26) TTC #1 Dx: MFI
2/12 IUI #1 - Clomid/HCG trigger = BFN
4/12 IVF #1 - 17r 14m 13f, 2 4AA blasts = BFN, 3 frosties
7/12 IVF #2 - 14r 13m 10f, 3 day 3 embies = BFP, 4 frosties
8/6/12 Beta #1 = 16, 8/15/12 Beta #5 = 72, 8/20/12 Beta #6 = 9. C/P
11/5/12 FET #1, 2 4AA blasts, 11/14/12 Beta #1 - 352, 11/16 Beta #2 - 1100
Vanishing twin, NT scan clear, 3/5/13 A/S
BabyFruit Ticker 
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11-16-2012 at 9:13 AM
BzeetyD
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We are at a similar place in our journeys, I think. This next IVF will be the last with our own eggs.

Improving egg quality is like the holy grail of IVF, it's very hard to fix, but protocols can be tweaked and may result in better numbers. 

I would also suggest a 2nd opinion. Look at some of the bigger, well known clinics (SIRM, CCRM, Cornell) or clinics in Chicago or NY. Some clinics, depending on your state, offer a free phone consult - with others the charge is around $250 or so - which is well worth it to either confirm your doc's opinion, or find out there may be more to the story.

I believe that you should continue with the PGD. If you have another set of abnormal embryos, it will be a very very hard pill to swallow, but maybe you'll be able to move on to your next step (DE or adoption or whatever) with a better sense of peace about the situation.

We are in this same spot and having no normals after testing is one of my fears, but I also feel it will help us to move forward, knowing we tried our best and did everything we could.

Putting back more than 1 embryo in with unknown abnormalities (non PGD tested) could put any sticky normal embryos at risk.

I would not blindly transfer more than 3 embryos myself and frankly, will not blindly put back any of our own embryos again without testing. It's worth it to us to avoid another loss.

Big huge hugs. 

Feel free to PM me any questions or just to vent.

BzeetyD = 37, Mr. BzeetyD = 43 together 12/02 married 9/08
TTC #1 since 1/10
DX: Unexplained/MFI issues
Long story: trying on our own + testing testing testing with 6 rounds of Clomid , more testing, injectables + TI, laparoscopy - one tube blocked, 2 IUIs with Follistim...BFNs.
RPL testing all normal

Moving on to IVF.

Our lil' lost sparks:
5w3d loss 7/30/10 - EDD March 2011
8w loss 4/15/11 - EDD November 2011
8w3d loss 8/2/12 - EDD March 2012
4w c/p loss 10/29/12 - EDD July 2012

IVF #1 April 2012 = BFN, IVF #2 June 2012 = BFP. U/S 7/23 = saw heartbeat but measuring behind. Follow up U/S on 7/30 - no heartbeat. D&C 8/2. Trisomy 12. IVF #3 Oct 2012 = Chemical Pregnancy

Phone consult with CCRM on 12/12/12 - ODWU 1/4/13 - both tubes clear(!) - AFC 24, AMH 3.2, FSH 9.6, LH 5.4, E2 25. DH has high frag rate but improved!
IVF #4 March 2013 CCRM. EP protocol w/ Menopur, Gonal-F & Dexamethasone. ER 3/29 & IMSI, PICSI. 43R 13M 10F 6blasts bio'd. CCS testing reveals 3 normals!!! FET 5/31/13



"I'm not telling you it's going to be easy, I'm telling you it's going to be worth it."

Everybody is welcome!!!  
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11-16-2012 at 11:26 AM
Crystal120...
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I dont have any advice I just wanted to say I'm so sorry that you are put in this awful situation. ::Hugs::
Married 9-10-11
Together 6 years before marriage
Me 26 DH 28
TTC since 9/2011
Dx endo 2007 Sx laparoscopy
End bcp 9/2011
Dx annovulatory, DOR, Low AMH
Hysteroscopy due to polyp 2-1-12
IUI#1-3 Cancelled due to low response
IUI#4 BFFN
IVF#1 8/30 Beta#1 256, 8/31 Beta#2 482 BFP!! M/C 5w3d
FET#1 Cancelled due to uterine fluid and thin lining
FET#1.2Cancelled due to abnormal bleeding
Hysteroscopy 12/28/12 All clear
FET#1.3 2/2013 Cancelled
FET #1.4 3/19 BFFN
Good Luck to All!!
Crystal
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11-16-2012 at 11:51 AM
Scoop77
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I don't have a lot of advice, but I just wanted to say that I strongly agree with the PPs who suggested getting a second opinion or another consult. Because, even in the best-case scenario, you're talking about waiting until January anyway, this is the perfect time for you to see what other doctors might recommend. GL!

TTC #1 for about 3.5 years
ME: 37, PCO, immune issues?, teflon uterus (my added diagnosis)
HIM: 38, Perfect. (Showoff.)
Month before starting Clomid, spontaneous pregnancy. m/c at 7 weeks and D&C.
Four months of Clomid, one IUI, with Intralipid each cycle: BFNs all
IVF 1.0 July 2012 -- Lupron, bravelle, menopur, estrogen, progesterone supps, intralipid. 14 ER, 14 fertilized, 1 blast transferred, 2 on ice. BFN
FET 1.1 -- 10/2, transferred our 2 blasts. Lupron, PIO, estrogen, baby aspirin, prednisone. BFN.
IVF 2.0 December 2012 -- Bravelle, Menopur, Ganirelix, Prednisone, Metformin, estrogen, progesterone supps. 22 eggs retrieved on 12/14, 17 mature, 15 fertilized. OHSS anticipated so ET cancelled. 3 embryos frozen.
Broke up with old RE. Moving on to new dude. Maybe the change of scenery will be just the trick for our frosties. On BCPs for possible April FET.

P/SAIF welcome 
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11-16-2012 at 2:22 PM
JSM0801
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I don't have any advice either but just wanted to say I am so sorry you are going through such a hard time with all of this. GL with whatever decision you make. 
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Me (33)- unexplained MH (35)- MFI due to Vericocele. Straight to IVF w/ICSI 9/12, Antagonist = BFN c/p, poor quality blasts, tested sperm dna fragmentation. Results all good, yay! New RE for IVF #2- 1/13., Long Lupron. ER on 1/22 -10R, 9M, 9F. Transfer on hold due to overstimming. FET in Feb. 2 frozen blasts. Another BFN & another c/p. RPL testing all negative besides MTHFR gene, vericocle repair surgery 4/12/13-Bilateral Grade 3 Vericocele found & fixed, IVF #3 with PGS 4/13- 11R, 9M, 9F. Transferred 2 normal=BFN, 3 normal on ice Everyone Welcome!!!
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11-16-2012 at 10:23 PM
Mayzie15
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I'm sorry you didn't get the news you hoped for but with everything you have mentioned - I would strongly recommend getting a second opinion. I wasn't in your exact situation but I have been close.  I got a second opinion and switched RE's - it was hard to do but I'm a lot happier with my new RE.  My thoughts are with you as you make this difficult decision.
Me 37 MH 40 - TTC since June 2010 - dx with Severe MFI. Straight to IVF with ICSI. IVF #1 - ER 06/13/12 - 9 Eggs Retrieved - 4 ICSI'd - only 2 fert. 06/15/12 - 2DT - 3 cell & 6 cell with fragmentation. Beta 06/29/12 - IVF #1 = BFN. 07/20/12 - WTF Appt -Told by our RE to quit IVF. Second Opinion from RE is good. IVF#2 - November 2012. Estradiol Pills Started 11/6. Stims start 11/16. ER 11/26 - 7 eggs retrieved - all mature. 4 fertilized with ICSI. ET 11/29 Transferred 3 embryos. Beta is 12/10. 1st Beta 81 2nd Beta 160 and 3rd beta 360!!! First U/S 12/21/12 - We saw one beautiful gest. sac. 2nd U/S is 01/04/2013 - H/B 183 02/05/13 - NT Scan - everything looks good and IT'S A BOY!!! EDD 08/19/12
"Everything will be okay in the end. If it's not okay, it's not the end."

BabyFruit Ticker 
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11-19-2012 at 11:14 PM
chucktgirl
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MrsGlitteryHooks:

I see we live in the same state! I'm so sorry that your head is spinning- that is a lot of information and a lot of money.

Have you gotten a second opinion? I think that's what I'd do if I were in your situation.

MrsGlitteryHooks, yes! I am a Michigander too! :)
After reading your recommendation, and the other ladies who also suggested a 2nd opinion, I will be researching that tomorrow. I'm pretty sure my insurance only covers the RE institute that I'm currently seeing, so I'll have to find that out, too.

 

My (old) BLOG: www.ivfbabyquest.wordpress.com
TTC since Jan 2010 with OPKs. Me: 41, Hypothyroidism, hetero MTHFR C677T, hetero Factor V Leiden (no previous clots) Dx: DOR due to AMA. Rx: 100mg Levothyroxin, FaBB tab, Spring Valley Prenatal Vitamins, Vitamin D. Hubby: 34, Hyperthyroidism, Fragile X carrier, Great swimmers!
Natural PG 9/27/11; MC at 8wks. Used Cytotec to expel: 1/20/12 (unpleasant)
First RE visit: 8/8/12, Saline Sonogram: 8/28/12(4cm unknown mass in upper left of uterus) 2nd Saline Sonogram: 10/2/12 (mass disappeared!) IVF injection class: 10/11/12
IVF #1: 10/17/12 Baseline: FSH- 9.4, E2- 24, LH- 3.7, Progesterone- 0.3. 6 follicles in my right ovary & 9 in my left. Rx: 150 Bravelle & 150 Menopur SQ in AM. 10/21/12: Add Ganirelix SQ in PM. 10/26/12: hCG Trigger IM. ER 10/28/12: 13R, 7M, 6F. 5 Made it to PGS. ET 11/2/12: CANCELED. PGS: All 5 have "severe abnormalities." Devastated. Begged RE for back-to-back IVFs; Started Provera 11/2/12. AF said FU and came anyway, destroying any chance for a Dec IVF. Maxed out lifetime IF meds insurance. I can barely breathe, waiting to get through this process, hoping for my take-home-baby.
IVF #2: 1/7/13 Baseline: FSH- 8.8, 4 follicles in my right ovary & 6 in my left. Rx: 150 Bravelle & 150 Menopur SQ in PM. 1/11/13: Add Ganirelix SQ in AM. 1/16/13: hCG Trigger IM. ER 1/18/13: 9R, 5M, 5F. 2 Made it to PGS. ET 1/23/13: CANCELED. PGS: All embryos have "multiple severe abnormalities." RE recommends we stop trying and focus on living childless, due to the repeated extremely poor quality of my eggs. I don't even know what to do with that.
IVF #3- NEW RE! 100% OOP: 3/1/13 Baseline: FSH- 9.6, E2- 61, Progesterone- 0.94, 3 follicles in my right ovary & 4 in my left. Rx: 150 Bravelle & 150 Menopur SQ in PM. 3/7/13: Add Ganirelix SQ in AM. hCG Trigger 3/9/13 SQ. 3/11/13 ER: 6R, 2M, 2F. Day 3: one 8 cell, grade 0. 3/16/13 Five day ET: one early blast, grade Fair. 3/24/13 Started period a day before beta. BFN.
IVF #4 (FINAL) (Added acupuncture to this cycle.): 3/25/13 WTF & Baseline: FSH-11.8, E2- 56, Progesterone- 0.84 3/26/13 Start stims. 3/30/13 u/s: 5 follicles in my right ovary & 4 in my left. Rx: 225 Bravelle & 225 Menopur SQ in PM. 3/31/13 Add Ganirelix SQ in AM. hCG Trigger 4/3/13 SQ. 4/5/13 ER: 5R, 3M, 3F naturally. Day 3: two 8 cell, grade 0, one 8 cell, grade 2 (Scale 0-best to 3-worst). 4/10/13 Five day ET: two blastocysts (the 3rd stopped growing.) 4/18/13 Beta: 2.5 BFFN.
No DE or adoption for us, FIRM.
That’s it for us. I am beyond devastated and have no idea how to proceed from here. My life has been forever altered by this experience. Best wishes to all in their journeys! 
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11-19-2012 at 11:16 PM
chucktgirl
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hootie123:
I would also consider getting a second opinion on your situation.  Are you not going to consider donor eggs yet? 

hootie, No, we are not interested in DE. But I agree, it looks like it's time for a second opinion!

My (old) BLOG: www.ivfbabyquest.wordpress.com
TTC since Jan 2010 with OPKs. Me: 41, Hypothyroidism, hetero MTHFR C677T, hetero Factor V Leiden (no previous clots) Dx: DOR due to AMA. Rx: 100mg Levothyroxin, FaBB tab, Spring Valley Prenatal Vitamins, Vitamin D. Hubby: 34, Hyperthyroidism, Fragile X carrier, Great swimmers!
Natural PG 9/27/11; MC at 8wks. Used Cytotec to expel: 1/20/12 (unpleasant)
First RE visit: 8/8/12, Saline Sonogram: 8/28/12(4cm unknown mass in upper left of uterus) 2nd Saline Sonogram: 10/2/12 (mass disappeared!) IVF injection class: 10/11/12
IVF #1: 10/17/12 Baseline: FSH- 9.4, E2- 24, LH- 3.7, Progesterone- 0.3. 6 follicles in my right ovary & 9 in my left. Rx: 150 Bravelle & 150 Menopur SQ in AM. 10/21/12: Add Ganirelix SQ in PM. 10/26/12: hCG Trigger IM. ER 10/28/12: 13R, 7M, 6F. 5 Made it to PGS. ET 11/2/12: CANCELED. PGS: All 5 have "severe abnormalities." Devastated. Begged RE for back-to-back IVFs; Started Provera 11/2/12. AF said FU and came anyway, destroying any chance for a Dec IVF. Maxed out lifetime IF meds insurance. I can barely breathe, waiting to get through this process, hoping for my take-home-baby.
IVF #2: 1/7/13 Baseline: FSH- 8.8, 4 follicles in my right ovary & 6 in my left. Rx: 150 Bravelle & 150 Menopur SQ in PM. 1/11/13: Add Ganirelix SQ in AM. 1/16/13: hCG Trigger IM. ER 1/18/13: 9R, 5M, 5F. 2 Made it to PGS. ET 1/23/13: CANCELED. PGS: All embryos have "multiple severe abnormalities." RE recommends we stop trying and focus on living childless, due to the repeated extremely poor quality of my eggs. I don't even know what to do with that.
IVF #3- NEW RE! 100% OOP: 3/1/13 Baseline: FSH- 9.6, E2- 61, Progesterone- 0.94, 3 follicles in my right ovary & 4 in my left. Rx: 150 Bravelle & 150 Menopur SQ in PM. 3/7/13: Add Ganirelix SQ in AM. hCG Trigger 3/9/13 SQ. 3/11/13 ER: 6R, 2M, 2F. Day 3: one 8 cell, grade 0. 3/16/13 Five day ET: one early blast, grade Fair. 3/24/13 Started period a day before beta. BFN.
IVF #4 (FINAL) (Added acupuncture to this cycle.): 3/25/13 WTF & Baseline: FSH-11.8, E2- 56, Progesterone- 0.84 3/26/13 Start stims. 3/30/13 u/s: 5 follicles in my right ovary & 4 in my left. Rx: 225 Bravelle & 225 Menopur SQ in PM. 3/31/13 Add Ganirelix SQ in AM. hCG Trigger 4/3/13 SQ. 4/5/13 ER: 5R, 3M, 3F naturally. Day 3: two 8 cell, grade 0, one 8 cell, grade 2 (Scale 0-best to 3-worst). 4/10/13 Five day ET: two blastocysts (the 3rd stopped growing.) 4/18/13 Beta: 2.5 BFFN.
No DE or adoption for us, FIRM.
That’s it for us. I am beyond devastated and have no idea how to proceed from here. My life has been forever altered by this experience. Best wishes to all in their journeys! 
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11-19-2012 at 11:26 PM
chucktgirl
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BAKERMOMHDS:

chucktgirl:
B) Try another round of IVF and hope I have some fertilized embryos that stick around until day 5 AND test as genetically normal (at an additional OOP fee of $3500) and hope they stick. RE says that 10% of PGD embryos have bad results, so they could be putting in bad embryos to begin with, OR they could be discarding GOOD ones!

!

This is what we just tried for IVF#3.  Our embies have NEVER made it to day 5.  We switched RE's / switched protocols and clinics this round (#3) and we have ONE (over the moon excited) ONE beautiful top quality blast out of 14 fertilized.  The blast was biopsied yesterday and we should have the PGD results next week.  It is expensive (2500$), but knowing if that blasty is chromosomally normal with a 95% confidence before transfer..is priceless to us. If you go this route also consider : you'll be doing a FET (no fresh transfer) and the freeze / thaw / biopsy processes can cause nominal damage.  When I spoke with the embryologist yesterday, she indicated with top quality day 5 embryo's the risk with freeze / thaw / biopsy is about a 7% loss.

No guarantee this will be our take home baby, but we definitely are feeling more optimistic :)

Good luck to you!!!


Thank you Baker! And good luck to you and your one perfect embie! You know it's sad when I'm envying your $2500 instead of my $3500. Obviously you were given a 5% error rate of the PGD testing. Our RE said ours is a 10% error rate. I don't know how to explain that. Obviously I also prefer your odds! But ours IS a fresh transfer. They get the results early Day 5 and do ET the same morning-- if they make it that long and are normal, which mine were not. I am VERY scared to NOT do the PGD, but I also have a hard time going against my RE's recommendation. I very much appreciate your input. The additional views are helping me hone my decision!

My (old) BLOG: www.ivfbabyquest.wordpress.com
TTC since Jan 2010 with OPKs. Me: 41, Hypothyroidism, hetero MTHFR C677T, hetero Factor V Leiden (no previous clots) Dx: DOR due to AMA. Rx: 100mg Levothyroxin, FaBB tab, Spring Valley Prenatal Vitamins, Vitamin D. Hubby: 34, Hyperthyroidism, Fragile X carrier, Great swimmers!
Natural PG 9/27/11; MC at 8wks. Used Cytotec to expel: 1/20/12 (unpleasant)
First RE visit: 8/8/12, Saline Sonogram: 8/28/12(4cm unknown mass in upper left of uterus) 2nd Saline Sonogram: 10/2/12 (mass disappeared!) IVF injection class: 10/11/12
IVF #1: 10/17/12 Baseline: FSH- 9.4, E2- 24, LH- 3.7, Progesterone- 0.3. 6 follicles in my right ovary & 9 in my left. Rx: 150 Bravelle & 150 Menopur SQ in AM. 10/21/12: Add Ganirelix SQ in PM. 10/26/12: hCG Trigger IM. ER 10/28/12: 13R, 7M, 6F. 5 Made it to PGS. ET 11/2/12: CANCELED. PGS: All 5 have "severe abnormalities." Devastated. Begged RE for back-to-back IVFs; Started Provera 11/2/12. AF said FU and came anyway, destroying any chance for a Dec IVF. Maxed out lifetime IF meds insurance. I can barely breathe, waiting to get through this process, hoping for my take-home-baby.
IVF #2: 1/7/13 Baseline: FSH- 8.8, 4 follicles in my right ovary & 6 in my left. Rx: 150 Bravelle & 150 Menopur SQ in PM. 1/11/13: Add Ganirelix SQ in AM. 1/16/13: hCG Trigger IM. ER 1/18/13: 9R, 5M, 5F. 2 Made it to PGS. ET 1/23/13: CANCELED. PGS: All embryos have "multiple severe abnormalities." RE recommends we stop trying and focus on living childless, due to the repeated extremely poor quality of my eggs. I don't even know what to do with that.
IVF #3- NEW RE! 100% OOP: 3/1/13 Baseline: FSH- 9.6, E2- 61, Progesterone- 0.94, 3 follicles in my right ovary & 4 in my left. Rx: 150 Bravelle & 150 Menopur SQ in PM. 3/7/13: Add Ganirelix SQ in AM. hCG Trigger 3/9/13 SQ. 3/11/13 ER: 6R, 2M, 2F. Day 3: one 8 cell, grade 0. 3/16/13 Five day ET: one early blast, grade Fair. 3/24/13 Started period a day before beta. BFN.
IVF #4 (FINAL) (Added acupuncture to this cycle.): 3/25/13 WTF & Baseline: FSH-11.8, E2- 56, Progesterone- 0.84 3/26/13 Start stims. 3/30/13 u/s: 5 follicles in my right ovary & 4 in my left. Rx: 225 Bravelle & 225 Menopur SQ in PM. 3/31/13 Add Ganirelix SQ in AM. hCG Trigger 4/3/13 SQ. 4/5/13 ER: 5R, 3M, 3F naturally. Day 3: two 8 cell, grade 0, one 8 cell, grade 2 (Scale 0-best to 3-worst). 4/10/13 Five day ET: two blastocysts (the 3rd stopped growing.) 4/18/13 Beta: 2.5 BFFN.
No DE or adoption for us, FIRM.
That’s it for us. I am beyond devastated and have no idea how to proceed from here. My life has been forever altered by this experience. Best wishes to all in their journeys! 
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11-19-2012 at 11:34 PM
chucktgirl
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DoublePortion:
I have no advice that wasn't mentioned by PPs but wanted to send you huge ((hugs)). One of the worst aspects of IF is that there never seems to be an option that is clear cut.

Yes! SUPER frustrating. If only there was a set path we could follow, that if we did absolutely everything we were told that we could get our take home baby. We all work so hard for it!

My (old) BLOG: www.ivfbabyquest.wordpress.com
TTC since Jan 2010 with OPKs. Me: 41, Hypothyroidism, hetero MTHFR C677T, hetero Factor V Leiden (no previous clots) Dx: DOR due to AMA. Rx: 100mg Levothyroxin, FaBB tab, Spring Valley Prenatal Vitamins, Vitamin D. Hubby: 34, Hyperthyroidism, Fragile X carrier, Great swimmers!
Natural PG 9/27/11; MC at 8wks. Used Cytotec to expel: 1/20/12 (unpleasant)
First RE visit: 8/8/12, Saline Sonogram: 8/28/12(4cm unknown mass in upper left of uterus) 2nd Saline Sonogram: 10/2/12 (mass disappeared!) IVF injection class: 10/11/12
IVF #1: 10/17/12 Baseline: FSH- 9.4, E2- 24, LH- 3.7, Progesterone- 0.3. 6 follicles in my right ovary & 9 in my left. Rx: 150 Bravelle & 150 Menopur SQ in AM. 10/21/12: Add Ganirelix SQ in PM. 10/26/12: hCG Trigger IM. ER 10/28/12: 13R, 7M, 6F. 5 Made it to PGS. ET 11/2/12: CANCELED. PGS: All 5 have "severe abnormalities." Devastated. Begged RE for back-to-back IVFs; Started Provera 11/2/12. AF said FU and came anyway, destroying any chance for a Dec IVF. Maxed out lifetime IF meds insurance. I can barely breathe, waiting to get through this process, hoping for my take-home-baby.
IVF #2: 1/7/13 Baseline: FSH- 8.8, 4 follicles in my right ovary & 6 in my left. Rx: 150 Bravelle & 150 Menopur SQ in PM. 1/11/13: Add Ganirelix SQ in AM. 1/16/13: hCG Trigger IM. ER 1/18/13: 9R, 5M, 5F. 2 Made it to PGS. ET 1/23/13: CANCELED. PGS: All embryos have "multiple severe abnormalities." RE recommends we stop trying and focus on living childless, due to the repeated extremely poor quality of my eggs. I don't even know what to do with that.
IVF #3- NEW RE! 100% OOP: 3/1/13 Baseline: FSH- 9.6, E2- 61, Progesterone- 0.94, 3 follicles in my right ovary & 4 in my left. Rx: 150 Bravelle & 150 Menopur SQ in PM. 3/7/13: Add Ganirelix SQ in AM. hCG Trigger 3/9/13 SQ. 3/11/13 ER: 6R, 2M, 2F. Day 3: one 8 cell, grade 0. 3/16/13 Five day ET: one early blast, grade Fair. 3/24/13 Started period a day before beta. BFN.
IVF #4 (FINAL) (Added acupuncture to this cycle.): 3/25/13 WTF & Baseline: FSH-11.8, E2- 56, Progesterone- 0.84 3/26/13 Start stims. 3/30/13 u/s: 5 follicles in my right ovary & 4 in my left. Rx: 225 Bravelle & 225 Menopur SQ in PM. 3/31/13 Add Ganirelix SQ in AM. hCG Trigger 4/3/13 SQ. 4/5/13 ER: 5R, 3M, 3F naturally. Day 3: two 8 cell, grade 0, one 8 cell, grade 2 (Scale 0-best to 3-worst). 4/10/13 Five day ET: two blastocysts (the 3rd stopped growing.) 4/18/13 Beta: 2.5 BFFN.
No DE or adoption for us, FIRM.
That’s it for us. I am beyond devastated and have no idea how to proceed from here. My life has been forever altered by this experience. Best wishes to all in their journeys! 
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11-19-2012 at 11:44 PM
chucktgirl
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Km672:
I am so sorry you are dealing with this! Personally, I don't think I could go through with blindly putting back multiple embryos and have a big risk of miscarrying. I don't know why your RE is saying PGD has a 10 percent error rate, I have done PGD for 3 cycles and was told it was much more accurate. Why do they need your decision so quickly? As you know, this is a big, expensive, emotional ordeal and your answer may be more clear after you and your husband have time to process.

Thank you! I don't know about the 10%, that's just what he's said.
As for the quick decision, it's because they are going to try to squeeze one more cycle in before the end of the year for me because a new huge ins deductible kicks in in January. There might be time to do a cycle with a Day 3 transfer, but the PGD testing place will be closed until January. That's why we have to decide right away if we want to go ahead with a non-tested Day 3 transfer-- got to get the meds set up. I definitely don't have time to wait even another month...that's stressing me out even more. I'm about at my max age that I'm willing to keep trying. But I also realize that another pregnancy that ends in m/c will also put an end to our trying. <sigh>. No right answer, it seems.


My (old) BLOG: www.ivfbabyquest.wordpress.com
TTC since Jan 2010 with OPKs. Me: 41, Hypothyroidism, hetero MTHFR C677T, hetero Factor V Leiden (no previous clots) Dx: DOR due to AMA. Rx: 100mg Levothyroxin, FaBB tab, Spring Valley Prenatal Vitamins, Vitamin D. Hubby: 34, Hyperthyroidism, Fragile X carrier, Great swimmers!
Natural PG 9/27/11; MC at 8wks. Used Cytotec to expel: 1/20/12 (unpleasant)
First RE visit: 8/8/12, Saline Sonogram: 8/28/12(4cm unknown mass in upper left of uterus) 2nd Saline Sonogram: 10/2/12 (mass disappeared!) IVF injection class: 10/11/12
IVF #1: 10/17/12 Baseline: FSH- 9.4, E2- 24, LH- 3.7, Progesterone- 0.3. 6 follicles in my right ovary & 9 in my left. Rx: 150 Bravelle & 150 Menopur SQ in AM. 10/21/12: Add Ganirelix SQ in PM. 10/26/12: hCG Trigger IM. ER 10/28/12: 13R, 7M, 6F. 5 Made it to PGS. ET 11/2/12: CANCELED. PGS: All 5 have "severe abnormalities." Devastated. Begged RE for back-to-back IVFs; Started Provera 11/2/12. AF said FU and came anyway, destroying any chance for a Dec IVF. Maxed out lifetime IF meds insurance. I can barely breathe, waiting to get through this process, hoping for my take-home-baby.
IVF #2: 1/7/13 Baseline: FSH- 8.8, 4 follicles in my right ovary & 6 in my left. Rx: 150 Bravelle & 150 Menopur SQ in PM. 1/11/13: Add Ganirelix SQ in AM. 1/16/13: hCG Trigger IM. ER 1/18/13: 9R, 5M, 5F. 2 Made it to PGS. ET 1/23/13: CANCELED. PGS: All embryos have "multiple severe abnormalities." RE recommends we stop trying and focus on living childless, due to the repeated extremely poor quality of my eggs. I don't even know what to do with that.
IVF #3- NEW RE! 100% OOP: 3/1/13 Baseline: FSH- 9.6, E2- 61, Progesterone- 0.94, 3 follicles in my right ovary & 4 in my left. Rx: 150 Bravelle & 150 Menopur SQ in PM. 3/7/13: Add Ganirelix SQ in AM. hCG Trigger 3/9/13 SQ. 3/11/13 ER: 6R, 2M, 2F. Day 3: one 8 cell, grade 0. 3/16/13 Five day ET: one early blast, grade Fair. 3/24/13 Started period a day before beta. BFN.
IVF #4 (FINAL) (Added acupuncture to this cycle.): 3/25/13 WTF & Baseline: FSH-11.8, E2- 56, Progesterone- 0.84 3/26/13 Start stims. 3/30/13 u/s: 5 follicles in my right ovary & 4 in my left. Rx: 225 Bravelle & 225 Menopur SQ in PM. 3/31/13 Add Ganirelix SQ in AM. hCG Trigger 4/3/13 SQ. 4/5/13 ER: 5R, 3M, 3F naturally. Day 3: two 8 cell, grade 0, one 8 cell, grade 2 (Scale 0-best to 3-worst). 4/10/13 Five day ET: two blastocysts (the 3rd stopped growing.) 4/18/13 Beta: 2.5 BFFN.
No DE or adoption for us, FIRM.
That’s it for us. I am beyond devastated and have no idea how to proceed from here. My life has been forever altered by this experience. Best wishes to all in their journeys! 
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11-20-2012 at 12:06 AM
chucktgirl
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chucktgirl is not online. Last active: 04-18-2013, 4:43 PMBronze
BzeetyD:

We are at a similar place in our journeys, I think. This next IVF will be the last with our own eggs.

Improving egg quality is like the holy grail of IVF, it's very hard to fix, but protocols can be tweaked and may result in better numbers. 

I would also suggest a 2nd opinion. Look at some of the bigger, well known clinics (SIRM, CCRM, Cornell) or clinics in Chicago or NY. Some clinics, depending on your state, offer a free phone consult - with others the charge is around $250 or so - which is well worth it to either confirm your doc's opinion, or find out there may be more to the story.

I believe that you should continue with the PGD. If you have another set of abnormal embryos, it will be a very very hard pill to swallow, but maybe you'll be able to move on to your next step (DE or adoption or whatever) with a better sense of peace about the situation.

We are in this same spot and having no normals after testing is one of my fears, but I also feel it will help us to move forward, knowing we tried our best and did everything we could.

Putting back more than 1 embryo in with unknown abnormalities (non PGD tested) could put any sticky normal embryos at risk.

I would not blindly transfer more than 3 embryos myself and frankly, will not blindly put back any of our own embryos again without testing. It's worth it to us to avoid another loss.

Big huge hugs. 

Feel free to PM me any questions or just to vent.

Thanks Bzeety. I know. My husband and I differ. For him, the hardest moment was being told that none of our embryos was normal. Yes, it sucked, but for me, having a m/c was way worse. So maybe that should be my answer. I don't know. I can make an argument for both. I was unaware of a phone consultation, but that sounds like a viable option. My RE also suggested that I get a second opinion, and recommended I look into Dr. Schoolcraft out of CCRM. At first I was thinking there is no way I could do an out of state process, but I guess at this point I can do almost anything. I will look into it.
Thanks for your honest opinions. I also really appreciate your offer as a listening ear! I am hoping you get your take home baby, too!

My (old) BLOG: www.ivfbabyquest.wordpress.com
TTC since Jan 2010 with OPKs. Me: 41, Hypothyroidism, hetero MTHFR C677T, hetero Factor V Leiden (no previous clots) Dx: DOR due to AMA. Rx: 100mg Levothyroxin, FaBB tab, Spring Valley Prenatal Vitamins, Vitamin D. Hubby: 34, Hyperthyroidism, Fragile X carrier, Great swimmers!
Natural PG 9/27/11; MC at 8wks. Used Cytotec to expel: 1/20/12 (unpleasant)
First RE visit: 8/8/12, Saline Sonogram: 8/28/12(4cm unknown mass in upper left of uterus) 2nd Saline Sonogram: 10/2/12 (mass disappeared!) IVF injection class: 10/11/12
IVF #1: 10/17/12 Baseline: FSH- 9.4, E2- 24, LH- 3.7, Progesterone- 0.3. 6 follicles in my right ovary & 9 in my left. Rx: 150 Bravelle & 150 Menopur SQ in AM. 10/21/12: Add Ganirelix SQ in PM. 10/26/12: hCG Trigger IM. ER 10/28/12: 13R, 7M, 6F. 5 Made it to PGS. ET 11/2/12: CANCELED. PGS: All 5 have "severe abnormalities." Devastated. Begged RE for back-to-back IVFs; Started Provera 11/2/12. AF said FU and came anyway, destroying any chance for a Dec IVF. Maxed out lifetime IF meds insurance. I can barely breathe, waiting to get through this process, hoping for my take-home-baby.
IVF #2: 1/7/13 Baseline: FSH- 8.8, 4 follicles in my right ovary & 6 in my left. Rx: 150 Bravelle & 150 Menopur SQ in PM. 1/11/13: Add Ganirelix SQ in AM. 1/16/13: hCG Trigger IM. ER 1/18/13: 9R, 5M, 5F. 2 Made it to PGS. ET 1/23/13: CANCELED. PGS: All embryos have "multiple severe abnormalities." RE recommends we stop trying and focus on living childless, due to the repeated extremely poor quality of my eggs. I don't even know what to do with that.
IVF #3- NEW RE! 100% OOP: 3/1/13 Baseline: FSH- 9.6, E2- 61, Progesterone- 0.94, 3 follicles in my right ovary & 4 in my left. Rx: 150 Bravelle & 150 Menopur SQ in PM. 3/7/13: Add Ganirelix SQ in AM. hCG Trigger 3/9/13 SQ. 3/11/13 ER: 6R, 2M, 2F. Day 3: one 8 cell, grade 0. 3/16/13 Five day ET: one early blast, grade Fair. 3/24/13 Started period a day before beta. BFN.
IVF #4 (FINAL) (Added acupuncture to this cycle.): 3/25/13 WTF & Baseline: FSH-11.8, E2- 56, Progesterone- 0.84 3/26/13 Start stims. 3/30/13 u/s: 5 follicles in my right ovary & 4 in my left. Rx: 225 Bravelle & 225 Menopur SQ in PM. 3/31/13 Add Ganirelix SQ in AM. hCG Trigger 4/3/13 SQ. 4/5/13 ER: 5R, 3M, 3F naturally. Day 3: two 8 cell, grade 0, one 8 cell, grade 2 (Scale 0-best to 3-worst). 4/10/13 Five day ET: two blastocysts (the 3rd stopped growing.) 4/18/13 Beta: 2.5 BFFN.
No DE or adoption for us, FIRM.
That’s it for us. I am beyond devastated and have no idea how to proceed from here. My life has been forever altered by this experience. Best wishes to all in their journeys! 
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11-20-2012 at 12:10 AM
chucktgirl
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chucktgirl is not online. Last active: 04-18-2013, 4:43 PMBronze
Thank you all! I really needed to hear some opinions. My husband and I just keep waffling. I will post any progress after I search for another RE's opinion. HUGS back to each of you!

My (old) BLOG: www.ivfbabyquest.wordpress.com
TTC since Jan 2010 with OPKs. Me: 41, Hypothyroidism, hetero MTHFR C677T, hetero Factor V Leiden (no previous clots) Dx: DOR due to AMA. Rx: 100mg Levothyroxin, FaBB tab, Spring Valley Prenatal Vitamins, Vitamin D. Hubby: 34, Hyperthyroidism, Fragile X carrier, Great swimmers!
Natural PG 9/27/11; MC at 8wks. Used Cytotec to expel: 1/20/12 (unpleasant)
First RE visit: 8/8/12, Saline Sonogram: 8/28/12(4cm unknown mass in upper left of uterus) 2nd Saline Sonogram: 10/2/12 (mass disappeared!) IVF injection class: 10/11/12
IVF #1: 10/17/12 Baseline: FSH- 9.4, E2- 24, LH- 3.7, Progesterone- 0.3. 6 follicles in my right ovary & 9 in my left. Rx: 150 Bravelle & 150 Menopur SQ in AM. 10/21/12: Add Ganirelix SQ in PM. 10/26/12: hCG Trigger IM. ER 10/28/12: 13R, 7M, 6F. 5 Made it to PGS. ET 11/2/12: CANCELED. PGS: All 5 have "severe abnormalities." Devastated. Begged RE for back-to-back IVFs; Started Provera 11/2/12. AF said FU and came anyway, destroying any chance for a Dec IVF. Maxed out lifetime IF meds insurance. I can barely breathe, waiting to get through this process, hoping for my take-home-baby.
IVF #2: 1/7/13 Baseline: FSH- 8.8, 4 follicles in my right ovary & 6 in my left. Rx: 150 Bravelle & 150 Menopur SQ in PM. 1/11/13: Add Ganirelix SQ in AM. 1/16/13: hCG Trigger IM. ER 1/18/13: 9R, 5M, 5F. 2 Made it to PGS. ET 1/23/13: CANCELED. PGS: All embryos have "multiple severe abnormalities." RE recommends we stop trying and focus on living childless, due to the repeated extremely poor quality of my eggs. I don't even know what to do with that.
IVF #3- NEW RE! 100% OOP: 3/1/13 Baseline: FSH- 9.6, E2- 61, Progesterone- 0.94, 3 follicles in my right ovary & 4 in my left. Rx: 150 Bravelle & 150 Menopur SQ in PM. 3/7/13: Add Ganirelix SQ in AM. hCG Trigger 3/9/13 SQ. 3/11/13 ER: 6R, 2M, 2F. Day 3: one 8 cell, grade 0. 3/16/13 Five day ET: one early blast, grade Fair. 3/24/13 Started period a day before beta. BFN.
IVF #4 (FINAL) (Added acupuncture to this cycle.): 3/25/13 WTF & Baseline: FSH-11.8, E2- 56, Progesterone- 0.84 3/26/13 Start stims. 3/30/13 u/s: 5 follicles in my right ovary & 4 in my left. Rx: 225 Bravelle & 225 Menopur SQ in PM. 3/31/13 Add Ganirelix SQ in AM. hCG Trigger 4/3/13 SQ. 4/5/13 ER: 5R, 3M, 3F naturally. Day 3: two 8 cell, grade 0, one 8 cell, grade 2 (Scale 0-best to 3-worst). 4/10/13 Five day ET: two blastocysts (the 3rd stopped growing.) 4/18/13 Beta: 2.5 BFFN.
No DE or adoption for us, FIRM.
That’s it for us. I am beyond devastated and have no idea how to proceed from here. My life has been forever altered by this experience. Best wishes to all in their journeys! 
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