Would DH be going with you? I flew with my son from GA to TX (only 2 hours) when my son was 6 weeks and it was rough. More so with all of the gear...and that was just one! Once we made it to our seat he just nursed the entire time. I would be scared to fly with a 2 year old and a newborn by myslef for that long but that's just me. My mom flew to Germany when I was 6 weeks and my brother was 4 and she made it fine. We were both throwing up at the same time and she was frazzled after but she made it!