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12-09-2012 at 4:09 PM
Manada
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Joined on 11-26-2012
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Manada is online. Last active: 05-18-2013, 7:14 PMNewbie

Anyone's clinics offer sperm sorting for genetic reasons?

Last week our doc sent my blood away for genetic testing related to my POF and at the same time mentioned the possibilities that I might be a Fragile X carrier. After some research and reading I realized I do have a greataunt who has a developmental disability, and one of her sons may also have FXS. They live in rural England, and none of our family here knows if they have ever even been genetically tested and we aren't in contact with them. My research has shown though that if I do have FXPOI then it is most likely a female child will not be as severely effected.

So, it will be at least a month before our genetic results come back, but our doc definitely advises we continue on with our iui plans as my fertility is in rapid decline. But after my research I can't help but wonder if maybe trying to "sort" the sperm to increase our chances of an xx chromosomed fetus is even something clinics regularly can offer?

My research has only turned up clinics in Mexico, or information on IVF w/PGD. I know that Ericcson or spinning sorting may only be 75 effective, but I am interested to know I'd anyone has had this come up with their clinic. We are also in Canada so I am not sure whether federal policy also factors in for sex selection for genetic reasons.

Same sex couple - 31 years old - donor sperm, carrying our first due to dx of DOR/POF in Nov. 2012.

Low AMH, AFC - 6, Normal FSH, SS-A (RO) Antibodies (Autoimmune issues), tubes clear

IUI# 1 - December 19 - Done too early (24-36hrs before Ovulation) - BFN

IUI# 2 - January 16 - Femara + HCG trigger - BFN

IUI# 3 - March - 150-225iui Puregon, stimmed 16 days with only 1 follicle - nearly missed surge so no trigger - Progesterone - BFN.

IUI # 4 - "Pokey-Pokey" April 9 - 100mg Clomid CD 3-7, HCG Trigger + Progesterone - 2 follicles! IUI done after one O'd and before the 2nd one did. - BFN

...Moving on to trying to get my Partner pregnant with donor sperm. Hoping to come back and try with me, or do IVF with my DP's eggs eventually. My nerves are too frazzled for now

Getting Married with a Love Party in June 2013 to the amazing Healz413!

 

12-09-2012 at 4:36 PM
LaineyPane...
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Joined on 08-05-2012
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LaineyPaney is not online. Last active: 05-18-2013, 8:13 AMSilver
Ummm....I don't know about sperm sorting, but I know that it was discussed at our clinic with male/female embryos with the phrase "family balancing" being used. Some families express a preference for a specific gender whether it has anything to do with a genetic condition or simply preference. But, as I mentioned---it was with embryos and IVF, not IUI in our discussion.

wedding countdown  
12-09-2012 at 5:05 PM
tptbabe
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Joined on 06-12-2002
5,192 Points
tptbabe is online. Last active: 05-18-2013, 7:26 PMBronze
I don't know about Ontario, but I'm pretty sure there's legislation against it in BC? (Because they have legislation against telling the sex of the baby.) If there's a genetic reasoning behind it though, then you might have a better chance of being able to have it done. Doesn't hurt to ask your RE about it!

My Ovulation Chart
TTC with MFI and poor ovulation since 03/11
TCM and progesterone supplements
Early loss in 08/11
MFI Dx in 03/12 Low count, low motility, poor morphology and high levels of anti-sperm antibodies
Treated with supplements and TCM. Much lower on all factors. Count too low to test for anti-bodies
Met with new urologist 11/12
IUI #1 12/12: Letrozole + Gonal-F = BFN
DH started Clomid 01/13
New SA shows 33 million sperm! Thank you Clomid!!!
Discovered I am hypothyroid 04/13 waiting for specialist appointment
Hoping to try IUI again in July?
 
12-10-2012 at 9:01 AM
Citygirl10...
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Joined on 02-16-2010
Philadelphia, PA
7,030 Points
Citygirl1015 is not online. Last active: 05-18-2013, 1:36 PMBronze

I'm sorry to hear about your potential Fragile X dx. I think the only way to really make sure you get a girl embryo would be to do IVF with PGD. Especially if your RE says your fertility is in rapid decline, this seems like the most logical option for you since IUI's have a much lower success rate than IVF.


TTC #1 since Oct 2009, Dx: Unexplained Infertility
HSG: Right tube all clear, left tube inconclusive
3 failed Clomid Cylces
4/5 lap revealed blocked left tube, but right tube is open
April/May- 50 mg Clomid + Ovidrel + IUI #1= CANCELLED left ovary ovulating
June 1- 100 mg Clomid + Ovidrel + IUI #1 = BFN
June 28- 100 mg Clomid + Ovidrel + IUI #2 =BFP!
7/12 Beta #1= 14 Beta #2= >5 Chemical Pregnancy :(
July-Nov long break to recover emotionally and financially
Nov 24- 100 mg Clomid + Ovidrel + IUI #3= BFN
Jan 22- Gonal-F + Ovidrel + IUI# 4 = CANCELLED no response on right
IVF #1- Start stims 4/7, ER 4/20, 21R, 14F, 6 frosties, ET 4/25, 2 embryos transferred= BFN :(
FET #1- June 2012, Lurpon starts 5/27- CANCELLED
FET #1 take 2- August 2012, delayed until Sept-CANCELLED
FET #1 take 3- ET 10/11, 2 embryos transferred,= BFFN
FET #2- Transfer 12/4--Cancelled, no embies survived thaw :(
Next steps-- IVF #2 with new RE in March
HOLY SURPRISE BFP 2/15/13!!!! Beta 1- 286, Beta 2- 782, U/S shows baby in uterus and healthy heartbeat


 BabyFruit Ticker

 
12-10-2012 at 10:32 AM
Manada
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Joined on 11-26-2012
7,882 Points
Manada is online. Last active: 05-18-2013, 7:14 PMNewbie

Thanks for your supportive responses everyone.

 This whole thing has thrown me for a loop, but on the weekend my partner and I volunteered at a local community center's kids holiday party, where there were a few kids I know in the community who have been adopted and who have special needs -- and we have decided to at least proceed with our planned iui this month (we're already on CD6), and know that if it works, then we will have a child who will be loved, and wanted, and we will make it work.   I've been doing alot of research on the local FX community, potential therapies and resources - it helps some.

 

That said, if I come back with a dx of a premutation carrier in January, then I think we will probably change our plan drastically - and probably switch to IVF, or just give up on getting me pregnant altogether (and instead focus on getting my partner pregnant).  As much as I feel like we can adjust to have a child with special needs - I don't want to be making a baby under as much stress and worry as I have been in this past week.   But that's a whole bunch of other sadness for me -- between POF and this I've been crying alot and feel like the universe doesn't want me to be pregnant!

 

But yeah - bottom line it looks like sperm sorting may not actually be an option.  We'll ask, but I don't think it's common.....  bah.

 

Thanks for your support.


Same sex couple - 31 years old - donor sperm, carrying our first due to dx of DOR/POF in Nov. 2012.

Low AMH, AFC - 6, Normal FSH, SS-A (RO) Antibodies (Autoimmune issues), tubes clear

IUI# 1 - December 19 - Done too early (24-36hrs before Ovulation) - BFN

IUI# 2 - January 16 - Femara + HCG trigger - BFN

IUI# 3 - March - 150-225iui Puregon, stimmed 16 days with only 1 follicle - nearly missed surge so no trigger - Progesterone - BFN.

IUI # 4 - "Pokey-Pokey" April 9 - 100mg Clomid CD 3-7, HCG Trigger + Progesterone - 2 follicles! IUI done after one O'd and before the 2nd one did. - BFN

...Moving on to trying to get my Partner pregnant with donor sperm. Hoping to come back and try with me, or do IVF with my DP's eggs eventually. My nerves are too frazzled for now

Getting Married with a Love Party in June 2013 to the amazing Healz413!

 

12-10-2012 at 3:16 PM
tptbabe
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Joined on 06-12-2002
5,192 Points
tptbabe is online. Last active: 05-18-2013, 7:26 PMBronze

Mt Sin.ai has an excellent urology program. I think that if anyone would know about it, it would be them? Good luck!


My Ovulation Chart
TTC with MFI and poor ovulation since 03/11
TCM and progesterone supplements
Early loss in 08/11
MFI Dx in 03/12 Low count, low motility, poor morphology and high levels of anti-sperm antibodies
Treated with supplements and TCM. Much lower on all factors. Count too low to test for anti-bodies
Met with new urologist 11/12
IUI #1 12/12: Letrozole + Gonal-F = BFN
DH started Clomid 01/13
New SA shows 33 million sperm! Thank you Clomid!!!
Discovered I am hypothyroid 04/13 waiting for specialist appointment
Hoping to try IUI again in July?
 
12-10-2012 at 3:55 PM
IBackBevo
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Joined on 01-09-2006
North Houston
22,975 Points
IBackBevo is not online. Last active: 05-18-2013, 7:12 PMSilver

I am a Fragile X carrier and have a healthy, beautiful son through an IUI. 

First, you don't know if you are a fragile x carrier. Your great aunt's disability may have nothing to do with fragile x. 

In order to have full-blown Fragile X, your son would have to have over 200 repeats.  It is unlikely that unless you have a very high number of repeats that in one generation it would mutate into full-blown Fragile X.  Also, most women with FXPOI (basically DOR or POF caused by the FMR1 mutation) don't tend to have a real high number of repeats...although, obviously it is higher than normal or they wouldn't be having the DOR/POF in the first place.  About 1/4th of all women who are Fragile X carriers experience DOR or POF.  All being a carrier means is that you have a higher than normal level of mutations.  Also, even if you had a boy, there is still only a 50/50 chance he would even get your bad "X."

FYI, there is a clinic (I think somewhere in VA) who will do what you are talking about, but it is expensive and complex (you would have to either go there for your IUI or you would have to have the sperm frozen and shipped there and then shipped back)...and there really isn't a reason to unless like I said above you have a very high number of repeats.   I think the better option, if you did have a high number of repeats would be to do IVF and get the genetic testing done on the embryos. 



DX: DOR & Fragile X premutation carrier
2011: FSH 13.3 & E 99; AMH 0.54 ~ 2nd FSH 6.2 E 40's AFC: 8
BFP from Clomid/IUI ~ Pre-e and IUGR during pregnancy ~ LO born 9/4/12
Feb. 2013: AMH less than 0.16 (undetectable) ~ FSH 6.8 (normal)
What is going on with my body? 
12-10-2012 at 4:06 PM
IBackBevo
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Joined on 01-09-2006
North Houston
22,975 Points
IBackBevo is not online. Last active: 05-18-2013, 7:12 PMSilver
Manada:

That said, if I come back with a dx of a premutation carrier in January, then I think we will probably change our plan drastically - and probably switch to IVF, or just give up on getting me pregnant altogether (and instead focus on getting my partner pregnant).  As much as I feel like we can adjust to have a child with special needs - I don't want to be making a baby under as much stress and worry as I have been in this past week.   But that's a whole bunch of other sadness for me -- between POF and this I've been crying alot and feel like the universe doesn't want me to be pregnant!

Thanks for your support.

I just read this reply and I wanted to say feel free to PM me if you have any questions. I also wanted to assure you again - Even if you come back as a carrier, the odds are greatly in your favor that your child will be fine.  There is a pretty low likelihood of having a Fragile X child unless you have a very high number of repeats even if you have a boy.



DX: DOR & Fragile X premutation carrier
2011: FSH 13.3 & E 99; AMH 0.54 ~ 2nd FSH 6.2 E 40's AFC: 8
BFP from Clomid/IUI ~ Pre-e and IUGR during pregnancy ~ LO born 9/4/12
Feb. 2013: AMH less than 0.16 (undetectable) ~ FSH 6.8 (normal)
What is going on with my body? 
12-10-2012 at 4:17 PM
IBackBevo
Not Ranked
Joined on 01-09-2006
North Houston
22,975 Points
IBackBevo is not online. Last active: 05-18-2013, 7:12 PMSilver

Here is a clinic that has done a bunch of research on POF/DOR/POI as it relates to the FMR1 mutations:

 http://www.centerforhumanreprod.com/about_scientific.html

The FMR1 mutation is basically the same thing as a Fragile X carrier.  It also has alot of interesting studies on how POF or DOR is a little different in women who have the FMR1 mutation.  For example, in one article they put forth the theory that it is not truly that we have run out of eggs, but that our bodies have trouble recruiting eggs in the early stages  - hence the low AMH/High FSH - and it isn't so much that we have completely run out of eggs.  Really, there is no way to tell how many eggs a person has left short of removing the ovaries and disecting them.



DX: DOR & Fragile X premutation carrier
2011: FSH 13.3 & E 99; AMH 0.54 ~ 2nd FSH 6.2 E 40's AFC: 8
BFP from Clomid/IUI ~ Pre-e and IUGR during pregnancy ~ LO born 9/4/12
Feb. 2013: AMH less than 0.16 (undetectable) ~ FSH 6.8 (normal)
What is going on with my body? 
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