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12-14-2012 at 3:01 PM
teridaniel...
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Joined on 07-06-2009
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teridanielle is not online. Last active: 05-14-2013, 2:21 PMNewbie

Lupron --- Anyone been told it oversuppressed them

As much of you know my first IVF got cancelled this week.  They coverted into an IUI for a last ditch effort to salvage what eggs I had produced.  I was cancelled, according to my RE, from a lack of response from the drugs.  I guess that means I was a poor responder to the long lupron protocol.  My RE believes that I am one of a small group of women that is "sensitive" to Lupron.  He stated he believes it oversuppressed me.  I had around 15 follies to start off with, but very few (only 4) grew to maturity by day so he decided to pull the plug.  Has anyone heard of this "sensitivity" to Lupron???  I have been trying to research this, but really can't find much on Mr. google about it. 

I will be on a new protocol come february (if this IUI is unsuccessful).  He wants to take Lupron out all together, do three weeks of BCPs, and start stimming with follistim and Menupor, with the addition of Ganirelix.  Has anyone had success with this protocol?  I've read this protocol is used mostly for woman w/ DOR/POF.  I asked specifically if he believed I suffered from this and he said absolutely not... so why the protocol?   I also read this protocol produces less eggs.  Well, agonist protocol I was on didn't produce a substanital amount of eggs so how is a protocol that produces less eggs supposed to help me???? 

 Sorry for the long drawn out saga, but I'm just trying to understand this IVF process.  Still upset I got cancelled :( 


All Welcome

Me: 29 DH: 30

IF DX severe endo SA: PERFECT!

7/16/2011 Married handsome hubby!
9/2012 Lap/Hystercopy DX w/ Stage III endo
Bilaterial Uterine Suspension/D&C/HSG
HCG/D&D on R/L ovaries/chromaltubation/Uterine Polyp
10/2012 RE consult. DX move straight to IVF
IVF #1 11/27/2012
IVF #1 Cancelled for Low Response and Converted to IUI #1 --- BFN

IVF #1.2 BCP 12/29 Stims 1/21 w/ New Protocol - Antongonist (225 Menopur, 150 Follistim, & Ganirelix)
ER 2/2/13 11R,9M,8F -- ET 2/7/13 2 Beautiful Perfect Blasts/5 made it Freeze! -- 2/12/12 +HPT -- 2/14/13 Beta #1 71 -- 2/18/2013 Beta #2 521 YAY! Let this be our take home baby!

Cutest girl in the world!! http://instagr.am/p/JVp-yUr_Ig/Mitzee's morning hair http://instagr.am/p/Lc2yjbr_BE/

 Pregnancy Ticker 
12-14-2012 at 3:22 PM
chiwifey
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chiwifey is not online. Last active: 05-18-2013, 8:21 AMSilver

***sig warning***

I hope it ok that I respond to your post. I still check in on the IF girls and am always sending t&ps for you all.

I was almost cancelled during IVF #1 with long lupron protocol. I only got 7 eggs and of those only 4 were mature. IVF 1 was a bust. So for IVF #2 we did the protocol your RE is suggesting (3 weeks bcp, follistim, menopur, & ganirelix). We got 13 eggs and 9 were mature. Definitely an improvement. While I didn't get pg with that IVF, I did with the FET using those embryos. I hope this makes sense. Basically I don't have any diagnosis except unexplained but we got much better results with the change in protocol.

Wishing you lots and lots of luck and tons of t&ps. This is a long, hard road but you can do it! 


TTC#1 since Oct. 2009
Dx with Unexplained IF
IUI #1-3, BFN
IVF #1 sept/oct 2011- BFN, IVF #2 nov/dec-BFFN
FET #1: 2/8 BFP!!!
chibaby born 10.29.12  
12-14-2012 at 3:54 PM
cupcake201
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4,968 Points
cupcake201 is not online. Last active: 05-18-2013, 10:07 PMBronze

I was on a long lupron protocol for my first IVF and we didn't have great results.  My E2 rose verrrry slowly and we ended up with 7 eggs but only 3 were mature.  My RE thinks I am overly sensitive to lupron and was oversuppressed.  We switched to a new RE for IVF #2 (for a variety of reasons) but he agreed and said he probably would've canceled me given my poor response if he had been my doctor then.  

We are moving forward with IVF #2 next month with an Estrogen Priming Protocol, which is an aggressive approach.  Hopefully this new protocol does toe trick for you and you see an improvement.   


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TTC#1 since 4/11 : m/c in 9/11 & 11/11
DH dx with Balanced Translocation 5/12
10/12 IVF#1-7R, 3M, 3F- No transfer - Froze 2.
IVF#2 1/13 - 11R, 10M, 6F, no transfer
IVF#3 4/13 - 8R, 6M, 6F, 1 passed PGD and was transfered 5/2/13
S/PAIF Welcome
 
12-14-2012 at 4:01 PM
J&D2007
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Joined on 02-22-2007
19,831 Points
J&D2007 is not online. Last active: 04-28-2013, 8:12 AMBronze
My RE never used the word 'oversuppressed', but she said I had a poor response to stims. I was on long lupron protocol with bravelle and menopur for stims. This time we are using 3 weeks of bcps followed by Microdose lupron for only 2 days before adding in stims (and much more stims). She never mentioned taking me off of lupron all together. Btw, I had 16 follicles to start and 5 retrieved/5mature.


Me: 35, DH: 36, ttc: 3+ years, dx: unknown
10/11: after 2 years, saw a RE, FSH 5.4
11/11: BFP! (surprise after thyroid med & normal hsg),
12/11: missed m/c after 7 week u/s,
1/12: D&C,
6/12 IUI #1: clomid, 5 mature follicles, excellent sperm,= BFN,
7/12: IUI #2: clomid, 3 mature follicles, excellent sperm= BFN,
8/12: IUi #3: clomid, 5 follicles, = BFP!, C/P
10/12 IVF #1: FSH 5.4, estradiol AFC: 14, long Lupron 150/bravelle75,5R/5M/4F, all 4 made it to 5dt, 1 blast and 1 8 cell transferred. No frosties. BFN
IVF #2: AFC 21, MD lupron 12/25, 225bravelle/150men, 4R/4M/3F, 5dt of 1 blast BFN
IVF #3: natural start antagon, starting 3/30, ER 4/11, 12R,11M,10F
.
[IMG]http://i248.photobucket.com/albums/gg174/pixydust3084/April_V2.jpg%5B/IMG] 
12-14-2012 at 5:43 PM
kflynn81
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Joined on 11-28-2009
Oak Lawn
28,209 Points
kflynn81 is not online. Last active: 05-15-2013, 9:10 PMBronze
I haven't had that happen with Lupron but it happened with the Ganirelix for me. For some reason it shut everything down and my cycle had to be cancelled. The microdose Lupron really worked well for me....in the sense that I've completed 2 cycles because of it.

Anniversary
Me(31): Possibly Adult Growth Hormone Deficiency caused by a mutation in my pituitary genes called PIT-1--Also, Factor V Leiden
DH (31): Borderline low morph, but not considered a problem
"Baby dancing" with no protection or BCP since July 2009
IF testing started March 2011
Endocrinology related tests from October 2011-February 2012
March 2012--Clomid --No response-Straight to injects!
April & May 2012-- IUI#1 & #2 = BFN
July 2012- IVF#1 cancelled
September 2012-IVF#1.2--BFN
November 2012- IVF #2 --BFN
January 2013- IVF #3-- BFFN
February 2013--Found a new RE but first back to the Endocrinologist for more diagnostic testing
Absolutely no idea when we can cycle again...looking into DE as well if IVF#4 fails again
PAIF/SAIF encouraged...give me some hope!!
For detailed cycle info. see right side of blog... Kate's IF Blog
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12-16-2012 at 7:45 AM
teridaniel...
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Joined on 07-06-2009
7,101 Points
teridanielle is not online. Last active: 05-14-2013, 2:21 PMNewbie
Thanks ladies! I'm hoping my next protocol works our better for me!

All Welcome

Me: 29 DH: 30

IF DX severe endo SA: PERFECT!

7/16/2011 Married handsome hubby!
9/2012 Lap/Hystercopy DX w/ Stage III endo
Bilaterial Uterine Suspension/D&C/HSG
HCG/D&D on R/L ovaries/chromaltubation/Uterine Polyp
10/2012 RE consult. DX move straight to IVF
IVF #1 11/27/2012
IVF #1 Cancelled for Low Response and Converted to IUI #1 --- BFN

IVF #1.2 BCP 12/29 Stims 1/21 w/ New Protocol - Antongonist (225 Menopur, 150 Follistim, & Ganirelix)
ER 2/2/13 11R,9M,8F -- ET 2/7/13 2 Beautiful Perfect Blasts/5 made it Freeze! -- 2/12/12 +HPT -- 2/14/13 Beta #1 71 -- 2/18/2013 Beta #2 521 YAY! Let this be our take home baby!

Cutest girl in the world!! http://instagr.am/p/JVp-yUr_Ig/Mitzee's morning hair http://instagr.am/p/Lc2yjbr_BE/

 Pregnancy Ticker 
12-16-2012 at 9:55 PM
new+tothis
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Joined on 07-18-2012
16,612 Points
new+tothis is not online. Last active: 05-18-2013, 9:48 PMBronze
I haven't started IVF yet but that's the protocol I'll be on (antagonist). My RE said she's choosing this for me because she's worried about OHSS. She's expecting a good number of eggs. She's hoping for 6-9 mature, fertilized eggs. I have low AMH but not low enough to have much of an impact on IVF. I also have endo.

TTC #1 for Dh, #2 for me. HSG clear. Low AMH and endo. Multiple Clomid w/TI cycles - all BFNs. 2 IUIs with Clomid and 1 with Femara - more BFNs. IVF#1 25R, 15M, 15F. 5DT of two perfect 4AA blasts! Positive HPT at 5dp5dt. Beta #1 6dp5dt - 72. Beta #2 8dp5dt - 285. Beta #3 10dp5dt - 793. Both babies have strong beautiful heartbeats! Baby B miscarried at 7 weeks. Baby A is holding on through miscarrying her twin, sub-chorionic hematoma, and complete placenta previa. Stick, baby, stick!

Lilypie Third Birthday tickers

Lilypie Maternity tickers 

12-17-2012 at 7:01 AM
nawlinsgrl
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Joined on 10-28-2009
21,876 Points
nawlinsgrl is not online. Last active: 05-18-2013, 4:46 PMBronze

I don't think there's anything wrong with trying the antagonist protocol.  That one worked for me the first time, but I did respond significantly better with the microdose lupron and a short dose of BCPs this time, and I was15 months older, which at my age, is significant. 

It is so hard to say what's best, because it depends on age and dx, both of which are different between us.  Also, I never used the long lupron, so I can't speak to the effects of that on my cycle.  Did you discuss microdose lupron as an option?  I would think if you did a shorter dose of BCPs with that, any oversuppression issues might be averted.


10/10: Married DH; 5/11: Dx: Blocked Fallopian Tube; 7/11: D&C/Hysteroscopy to remove polyp
IVF #1: 9/11: ER: 12R, 11M, 10F, No Frosties; 5dt: 2 blasts, 1 morula; DD born 6/3/12
IVF #2: 11/12-12/12: ER: 20R, 20M, 16F, 4 Frosties; 5dt: 3 blasts, DS EDD: 8/23/13
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