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12-19-2012 at 7:13 PM
brooklynes...
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Update

So, I finished my Hail Mary b2b IUIs today.  So far so good, though it looks like I only had one follicle so it's not like my chances are much greater than in a normal month (no MFI so the IUI aspect theoretically doesn't make much of a difference).  

Some of you might recall that I have a serious egg maturity issue.  Today, right after my second IUI, over 48 hours post HCG trigger, they measured my progesterone.  It was 3.2, which was just barely ovulatory (they consider anything 3+ ovulatory).  My 7 day progesterone is usually 12+.  The nurse who gave me my results thinks I must have just been ovulating when I was getting my second IUI.  If this is actually the case, it means I take 12+ hours longer to respond to the trigger than average, which may be the reason that during IVF I get almost no mature eggs.  Not sure how we'll use this information, but it's interesting to have.

So now I'm in another 2ww.  I'm not very optimistic but at least I feel like I'm doing something. 


Me: 39. DH: 41. TTC since 2009.
FSH: 9.5 at highest. AMH (11/2011): 0.9. AFC: 10ish. HSG: Normal. SA: Normal.
July 2011 - Feb. 2012: 2 Clomid/TI cycles; 3 injectables/IUI cycles. Good response but BFNs.
Dec. 2011: Laparoscopy (clear) + hysteroscopy to remove uterine polyp.

April 2012: IVF #1: FSH 9.2, AFC 7-8. Antagonist protocol.
Started stims (300iu Gonal-F, 150iu Menopur) 3/28.
Added ganirelix 4/1. Trigger 4/5 (7 follies). ER 4/7: 7R, 0M, 0F. :-(

Nov. 2012: IVF #2: Long Lupron protocol.
Started Lupron 10/27. AFC 10+. Started stims (300iu Follistim, 150iu Menopur) 11/8.
Trigger 11/18 (7 follies). ER 11/20: 9R, 1M, 1F. 3dt of my one 6-cell embie on 11/23: BFN.

Dec. 2012: Hail Mary IUI cycle with leftover IVF meds: BFN.

Feb. 2013: IVF #3: Estrogen priming protocol.
Pre-AF: estro patch + ganirelix. AFC 8-10. Started stims (450 Follistim, 150 Menopur) 1/28.
Added ganirelix 2/4. Combined Lupron/HCG trigger 2/10 (6-ish follies).
ET 2/12: 6R, 1M, 1F w/rescue ICSI. My embie didn't make it. :-(

July 2013: DE IVF #1

PAIF/SAIF/PA35 welcome.

Daisypath Anniversary tickers 
12-19-2012 at 7:25 PM
QOTR
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good luck!  I hope the 2WW passes quickly for you.

Me-40, Hubby-39. 1st BFP-8/17/12! Missed Miscarriage discovered @ 8 week US. D&C. 2nd BFP-2/13/13! Blighted Ovum discovered @ 8 week US. Natural miscarriage. Engaged RE assistance 4/2013. AMH=1.5; FSH=8; Estridol=25. Mosaic X chromosome and MTHFR C677T & A12986 heterozygous issues identified. HSG results = clear. 3rd BFP-5/22/13! By early June, progesterone plummeting. Another loss.  
12-19-2012 at 9:11 PM
Lenox1975
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You must be exhausted! Good luck!

Me: 37 DH: 37 TTC since Jan 2012. RE consult and initial testing done in Aug 2012: SA fine, AMH 1.1 & HSG clear - on way to IUI but got BFP on 9/10/2012. m/c 10/3/2012 at 6w5d. BFP next cycle which was a c/p. IUI #1: Clomid 100mg 12/6= BFN. IUI#1.5 (unmedicated) Jan 2013 = BFN. Hysteroscopy 1/25/13. IUI#2 Clomid 100mg 2/23 = BFN IUI#3 Clomid 100mg = BFN. IVF #1 April 2013: Menopur & Gonal F, ER=4/21, 9 retrieved, 8 mature, 2 fertilized. Transferred both (8cell) on 4/24. BFP=5/6 All Welcome!
 
12-19-2012 at 9:28 PM
HeathernSt...
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good luck!!

My Ovulation Chart Me: 40 DH: 45. We are TTC our 1st, started July '11, 3 cycles clomid with Ob, 1 cycle Tamoxifen with Ob, Diagnosed PCOS 11/5/12 clomid, trigger & timed bd 12/12 BFN 1st clomid IUI 1/4/13 BFN. 2nd clomid IUI 2/13 cancelled didn't respond to clomid. 3/29/13 laparoscopy - lft ovary attached to uterine wall & imobile fallopian tube fixed & on bcp. Hoping this ends our streak of bfn's! Started bravelle 5/2/13..... 
12-19-2012 at 10:09 PM
10-4LilBud...
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Good luck!

♥ TTC#1 since 2/10 ♥
DX: Me - Slight androgen PCOS Him: Mild MFI Official DX: Unexplained IF
2/11 - 8/11 - 6 cycles Femara (5mg) + TI = BFNs
2/12 - 5/12 - Femara(5mg) + IUI = BFNs
6/12 and 8/12 - Femara (7.5mg) + IUI = BFN :( - considered IUI#3 and 4 by RE
9/12 and 12/12 - Femara (7.5mg for 3 days) + Ovidrel + IUI = BFN
After 8 unsuccessful IUIs and no explanation for IF, moving on to IVF Feb. 2013. IVF with ICSI. 10 eggs fertilized - transferred two and froze three.
BFP! Beta #1 (13dpo) 98 Beta #2 (15dpo) 277 Beta #3 (17 dpo) 874 Beta #4 (22 dpo) 9658
3/20 - First ultrasound - TWO heartbeats!!! Due 11/12/13!

Lilypie Pregnancy tickers 
12-19-2012 at 10:24 PM
ELF4321
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Rockland County, NY
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ELF4321 is not online. Last active: 06-19-2013, 9:07 PMGold
FX for you!


Always missing my Mommy (1954-2010) and Daddy (1943-2012)
TTC since 2009 ; BFP 9/13/10 = MC 10/21/10
DX = DOR/POA (AMH=1.1; AFC=4-5)
Surprise BFP 8/31/11 while waiting to cycle for IVF
Welcomed our little miracle 5/7/12
 Baby Birthday Ticker Ticker
 
12-20-2012 at 5:37 AM
owlprof
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Wouldn't it be great if you finally figured out the problem and you can solve your maturity problems?  Fingers crossed for you this cycle!


TTC since Jan 2011,
5 IUIs from January to October 2012 = all BFN
IVF #1, ER scheduled for mid-December  
12-20-2012 at 5:45 AM
happywifem...
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happywifemomofone is not online. Last active: 06-19-2013, 9:37 PMSilver

owlprof:
Wouldn't it be great if you finally figured out the problem and you can s

olve your maturity problems?  Fingers crossed for you this cycle!

This, good luck!


TTC since 10/09 Me-44 DH-45 RE and testing 10/10-11/10, Recommending IVF 1/11 New RE AMA and DOR-DH low motility IVF #1.1 cancelled 3/11 due to poor response IVF #1.2 May 2011, one perfect 8-cell embryo, 3dt-BFN, IVF #2.1 Converted to IUI d/t poor response. New RE 9/2011. IVF 2.2 completed using HGH,EPP,DHEA, Q-10 and accupuncture. Transferred one 8-cell, grade one embryo on 10/19. BFP 10/31/11 Chemical pregancy on 11/2/11. Started stims for IVF #3, our final try, on 12-2-11. ET on 12/18. Transferred 3 Grade A embryos-BFFN DE IVF 22R, 15M, 13F. Transferred 2-4AB Blasts on 4/7. 6 frosties. Beta #1 at 8dp5dt- 166!!!Beta #2-344 at 10dp5dt Beta #3-719@ 12dp5dt. u/s 4/24 showed one gestational sac, heartbeat 124/min on 5/2.  
12-20-2012 at 7:18 AM
Qzees
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It only takes one Big Smile  I hope this time it works!!!

My Ovulation Chart || Ovulation Calendar Me 42, DH 34 - TTC #1 since June 2012. 9/12 3-day testing: TSH 3.76, T4 Free 1.1, LH 6.1, FSH 7.4, Prolactin 9.0, Estradiol 56. 12/12 HSG done & my tubes are clear!! 1/22/13 3-day testing: TSH 6.2, FSH 7.7, AMH 0.86, Estradiol 54, Prolactin 10.5. Thyroid almost doubled (hmmm), started Synthroid 2/4/13 and also 15,000 of Vit D 1/wk. 2/26/13 RE says I am in great shape, but DH has MFI - extremly low count along with morphology & motility issues. RE said IUI would be a waste, that IVF with ICSI is what he thinks we should do. Insurance does not cover IVF.... :( DH trying Fertility Blend to help his numbers. 4/15/13 tested my thyroid level again & I am down to 2.71. Too bad I gained 10lbs & I am more tired than I was prior to the meds. 
12-20-2012 at 8:26 AM
robbensm
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happywifemomofone:

owlprof:
Wouldn't it be great if you finally figured out the problem and you can s

olve your maturity problems?  Fingers crossed for you this cycle!

This, good luck!

Same here! Fingers crossed for you


My Ovulation Chart
|| Ovulation Calendar Me 38 & PCOS, DH 41. Went of BCP when we got married in Nov 2011, seriously TTC since March 2012. Six cycles of clomid = BFNs. Suspected endometriosos & HSG showed both tubes blocked so researching IVF.  
12-20-2012 at 11:08 AM
brooklynes...
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Joined on 08-10-2011
11,732 Points
brooklynesque is not online. Last active: 06-19-2013, 11:25 PMSilver
Thanks, everybody.

Me: 39. DH: 41. TTC since 2009.
FSH: 9.5 at highest. AMH (11/2011): 0.9. AFC: 10ish. HSG: Normal. SA: Normal.
July 2011 - Feb. 2012: 2 Clomid/TI cycles; 3 injectables/IUI cycles. Good response but BFNs.
Dec. 2011: Laparoscopy (clear) + hysteroscopy to remove uterine polyp.

April 2012: IVF #1: FSH 9.2, AFC 7-8. Antagonist protocol.
Started stims (300iu Gonal-F, 150iu Menopur) 3/28.
Added ganirelix 4/1. Trigger 4/5 (7 follies). ER 4/7: 7R, 0M, 0F. :-(

Nov. 2012: IVF #2: Long Lupron protocol.
Started Lupron 10/27. AFC 10+. Started stims (300iu Follistim, 150iu Menopur) 11/8.
Trigger 11/18 (7 follies). ER 11/20: 9R, 1M, 1F. 3dt of my one 6-cell embie on 11/23: BFN.

Dec. 2012: Hail Mary IUI cycle with leftover IVF meds: BFN.

Feb. 2013: IVF #3: Estrogen priming protocol.
Pre-AF: estro patch + ganirelix. AFC 8-10. Started stims (450 Follistim, 150 Menopur) 1/28.
Added ganirelix 2/4. Combined Lupron/HCG trigger 2/10 (6-ish follies).
ET 2/12: 6R, 1M, 1F w/rescue ICSI. My embie didn't make it. :-(

July 2013: DE IVF #1

PAIF/SAIF/PA35 welcome.

Daisypath Anniversary tickers 
12-20-2012 at 11:23 AM
BAKERMOMHD...
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happywifemomofone:

owlprof:
Wouldn't it be great if you finally figured out the problem and you can s

olve your maturity problems?  Fingers crossed for you this cycle!

This, good luck!

Ditto this!!! I'm really hoping this is successful for you!!!


Me = 39 DH = 50 TTC (since 01/2009 after a short break, I stopped counting *cycles* in 2010) DX 2010 : Unknown Infertility , AMA HSG 2005 = Normal / HSG 2010 = Normal SA 2005 = Normal / SA 2010 /2012 = Slightly low count : motility, morphology GREAT! Chromosomal analysis, MTHFR, ANA's, Lupus, Protein C, Protein S, APCR = Normal 2011
M/C : 2005 (7wk), 2010 (6wk), 2011 (7wk)
8 IUI's 2010-2011 all BFN
IVF/ICSI antagonist 01/2012 #1 = BFN
IVF/ICSI antagonist long 06/2012 #2 = BFN
IVF/ICSI/CGH MDLF New Clinic/New RE 11/2012 #3 = One beautiful boy blasty frozen PGS normal
IVF/ICSI/CGH MDLF 02/2013 #4 = One more beautiful boy blasty frozen PGS normal
SAIF / PAIF always welcome ****
 
12-20-2012 at 4:06 PM
ELF4321
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Joined on 05-20-2004
Rockland County, NY
18,818 Points
ELF4321 is not online. Last active: 06-19-2013, 9:07 PMGold

owlprof:
Wouldn't it be great if you finally figured out the problem and you can solve your maturity problems?  Fingers crossed for you this cycle!

Taken out of context, that would sound really rude.  LOL.



Always missing my Mommy (1954-2010) and Daddy (1943-2012)
TTC since 2009 ; BFP 9/13/10 = MC 10/21/10
DX = DOR/POA (AMH=1.1; AFC=4-5)
Surprise BFP 8/31/11 while waiting to cycle for IVF
Welcomed our little miracle 5/7/12
 Baby Birthday Ticker Ticker
 
12-20-2012 at 8:31 PM
PPL2011
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PPL2011 is not online. Last active: 06-19-2013, 10:59 PMBronze

brooklynesque...could you explain for me what you mean by "egg maturity issue"...do you think your eggs don't get big enough before they rupture the follicle?

Can I also ask what kind of stims you used?

I know it's hard to be optimistic, but I'll be optimistic for you! Hang in there and good luck with this cycle! 


41.5 yrs old/Husband 49.2 (no mfi). 01/2011 natural BFP- 02/24/2011 natural miscarriage at 8w0d. 01/2012 1cm polyp inside my uterus removed during Hysteroscopy. 02/2012 Unmedicated IUI #1 BFP, 04/2012 Baby stopped growing D&C at 8w2d. Blood Chromosome Analysis for me and DH-normal. MTHFR (positive for one copy C677T-heterozygous). PAI-1 (positive for one copy 4G Varient-heterozygous). Positive ANA 1:80. Taking Citra Natal plus DHA, Metanx, Synthyroid (for subclinical hypothyroid), CoQ10, Vit D, and Daily Baby Aspirin. 07/2012 AMH 1.8, FSH 7, AFC 16ish. 08/2012 Mini-Lap MYOMECTOMY to remove 3 intramural fibroids. 10/2012 IUI #2 (no meds except trigger) BFN. 11/2012 IUI #3 Gonal F, trigger, endometrin. BFN. 12/2012 IUI #4 Gonal F, trigger, endometrin. BFN. 01-02/2013 IVF #1 MDL protocol (20mdl, 450 follistim, 150 menopur). 13R, 10M, 8F, 6 went to PGS. PGS results=6 genetically abnormal. 03/13-New RE 04/13-05/13 IVF #2 Follistim (not much)/Menopur (a ton)/Ganirelix. 21R, 15M, 12F, 9 blasts, PGS results=9 genetically abnormal. DEVASTATION but marching on... July 2013-IVF #3 Lilypie Assisted Conception tickers 
12-21-2012 at 6:54 AM
brooklynes...
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Joined on 08-10-2011
11,732 Points
brooklynesque is not online. Last active: 06-19-2013, 11:25 PMSilver
ELF4321:

owlprof:
Wouldn't it be great if you finally figured out the problem and you can solve your maturity problems?  Fingers crossed for you this cycle!

Taken out of context, that would sound really rude.  LOL.

LOL. No medical treatment can solve those for me.  ;-) 


Me: 39. DH: 41. TTC since 2009.
FSH: 9.5 at highest. AMH (11/2011): 0.9. AFC: 10ish. HSG: Normal. SA: Normal.
July 2011 - Feb. 2012: 2 Clomid/TI cycles; 3 injectables/IUI cycles. Good response but BFNs.
Dec. 2011: Laparoscopy (clear) + hysteroscopy to remove uterine polyp.

April 2012: IVF #1: FSH 9.2, AFC 7-8. Antagonist protocol.
Started stims (300iu Gonal-F, 150iu Menopur) 3/28.
Added ganirelix 4/1. Trigger 4/5 (7 follies). ER 4/7: 7R, 0M, 0F. :-(

Nov. 2012: IVF #2: Long Lupron protocol.
Started Lupron 10/27. AFC 10+. Started stims (300iu Follistim, 150iu Menopur) 11/8.
Trigger 11/18 (7 follies). ER 11/20: 9R, 1M, 1F. 3dt of my one 6-cell embie on 11/23: BFN.

Dec. 2012: Hail Mary IUI cycle with leftover IVF meds: BFN.

Feb. 2013: IVF #3: Estrogen priming protocol.
Pre-AF: estro patch + ganirelix. AFC 8-10. Started stims (450 Follistim, 150 Menopur) 1/28.
Added ganirelix 2/4. Combined Lupron/HCG trigger 2/10 (6-ish follies).
ET 2/12: 6R, 1M, 1F w/rescue ICSI. My embie didn't make it. :-(

July 2013: DE IVF #1

PAIF/SAIF/PA35 welcome.

Daisypath Anniversary tickers 
12-21-2012 at 7:03 AM
brooklynes...
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Joined on 08-10-2011
11,732 Points
brooklynesque is not online. Last active: 06-19-2013, 11:25 PMSilver
PPL2011:

brooklynesque...could you explain for me what you mean by "egg maturity issue"...do you think your eggs don't get big enough before they rupture the follicle?

Can I also ask what kind of stims you used?

I know it's hard to be optimistic, but I'll be optimistic for you! Hang in there and good luck with this cycle! 

Hi, PPL.  We know that in IVF cycles, at least, my eggs generally don't mature -- they don't progress to the stage where they could fertilize.  "Mature" can be a misleading word, though.  It can mean I haven't stimmed long enough, or that the trigger didn't fully ripen my eggs in the previous 36 hours, or it could mean that something about the protocol itself damaged my eggs so they can't make it through the final stage of development.  It could also mean I just have really bad eggs.  Or some combination of the above.

My doctor told me that she suspects an issue for me might be my reaction to the trigger shot.  I think she may be right -- I used to temp through IUI cycles and my temperature wouldn't rise until the day after you'd think it would if I had ovulated when I was supposed to.  There's a chance that my eggs mature normally if given enough time after trigger (who knows).  So that's one reason we decided to try the b2b IUIs this month and to test my progesterone.  (That, and I had leftover stims and Crinone from previous cycles so the drugs were practically free.) 

Not sure how to convert this theory/knowledge for use in an IVF cycle, though.  In IVF if you guess wrong and wait more than 36-38 hours post-trigger when you really O on time, you risk getting no eggs at all.  But for me given my track record that may not be much of a risk. 


Me: 39. DH: 41. TTC since 2009.
FSH: 9.5 at highest. AMH (11/2011): 0.9. AFC: 10ish. HSG: Normal. SA: Normal.
July 2011 - Feb. 2012: 2 Clomid/TI cycles; 3 injectables/IUI cycles. Good response but BFNs.
Dec. 2011: Laparoscopy (clear) + hysteroscopy to remove uterine polyp.

April 2012: IVF #1: FSH 9.2, AFC 7-8. Antagonist protocol.
Started stims (300iu Gonal-F, 150iu Menopur) 3/28.
Added ganirelix 4/1. Trigger 4/5 (7 follies). ER 4/7: 7R, 0M, 0F. :-(

Nov. 2012: IVF #2: Long Lupron protocol.
Started Lupron 10/27. AFC 10+. Started stims (300iu Follistim, 150iu Menopur) 11/8.
Trigger 11/18 (7 follies). ER 11/20: 9R, 1M, 1F. 3dt of my one 6-cell embie on 11/23: BFN.

Dec. 2012: Hail Mary IUI cycle with leftover IVF meds: BFN.

Feb. 2013: IVF #3: Estrogen priming protocol.
Pre-AF: estro patch + ganirelix. AFC 8-10. Started stims (450 Follistim, 150 Menopur) 1/28.
Added ganirelix 2/4. Combined Lupron/HCG trigger 2/10 (6-ish follies).
ET 2/12: 6R, 1M, 1F w/rescue ICSI. My embie didn't make it. :-(

July 2013: DE IVF #1

PAIF/SAIF/PA35 welcome.

Daisypath Anniversary tickers 
12-21-2012 at 5:58 PM
BeckyP005
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BeckyP005 is not online. Last active: 06-19-2013, 7:34 PMSilver
Fingers crossed for you!

ME:45 MH:42 DE IVF 2013
Matrix Ollie
 
12-22-2012 at 5:04 PM
Jacque Sil...
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Jacque Sills is not online. Last active: 06-19-2013, 4:15 PMBronze
I saw your post and just wanted to let you know that you will be in my thoughts and prayers. I hope that your IUI cycle goes well. And, your holidays will be filled with Love, Laughther and great memories to share in the future!! :)

Lilypie Trying to Conceive 15 to 80 day cycle tickers 
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