Unexplained IF with IVF failure testing?

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12-20-2012 at 9:25 AM

megs3084

Joined on 12-26-2008

Chicago

2,033 Posts

28,319 Points

megs3084 is not online. Last active: 05-23-2013, 5:06 AM

Unexplained IF with IVF failure testing?

Hey all, I'll prob XP this onto PAIF for their input too, but I'm curious about everyones experiences here. I know I'm slightly putting the cart before the horse since my beta is tomorrow, but so far all the tests have been BFNs. For those of you that are unexplained and have had a failed IVF cycle, did your RE do any additional testing? I have had the cd3 labs, afc u/s, hsg and an amh level (I'll find out what it is tomorrow) and multiple SAs & hormone levels on DH. Is there anything else I should consider?

"Everything will be alright in the end. So if it's not alright, it is not yet the end."
"She wasn't bitter. She was sad, though. But it was a hopeful kind of sad. The kind of sad that just takes time." The Perks of Being a Wallflower

Me:28 DH:28 TTC since 1/11 Dx: unexplained IF/early DOR
Feb'12- Clomid/TI with CD3 &21 labs(normal)& SA-count 6mil/ml,morph/motil OK-BFN
April'12 Ultrasounds,HSG -clear, slight acurate uterus
5/14 IUI #1-50 mg clomid-post wash total motile count 19.3 prometrium 2dpiui= BFN
6/11-IUI #2-100 mg clomid & prometrium post wash count total motile 17.5 = BFN
7/6 IUI#3 with 100 mg clomid, estridiol, prometrium. post wash total motile count 23.3 = BFN
8/30IVF#1 BCPs, Follistim, Menopur,Ganerelix,Novarel.
ER 9/11-8R, 7M, 5F.
ET 9/14 2 embies transferred. 1 10cell Grade 4, 1 8cell Grade 4. No frosties. BFN
IVF#2 BCPs, Follistim, Menopur, Ganerelix, Novarel, Baby Aspirin
ER 12/5-16R, 12M, 8F!
ET 12/10 5dt! 1 fully expanded blast & 1 early blast. No frosties. BFN
2/13- Saline sono revealed a polyp. All additional labwork coming back normal. Genetic screen revealed DH has MTHFR deficiency & I am a carrier for it.
3/13 hysteroscopy & polypectomy
3/27 Began working with Reproductive Immunologist Dr. Kwak-Kim. Found High NK cells, High DHEAs, slight hypothyroidism, tendency toward blood clots (High PAI-1)Began synthroid & metformin 4/19.
Cycling in July

Here Comes the Sun Blog
PAIF/SAIF welcome!

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12-20-2012 at 9:35 AM

twistsandt...

Joined on 03-03-2012

2,073 Posts

30,091 Points

twistsandturnsto2 is not online. Last active: 05-23-2013, 3:30 PM

No advice here, but I hope those pee sticks are wrong! FX!

Me: 34, DH: 30 :: TCC since 2/11
SA: Perfect! CD3 b/w=Elevated Prolactin? HSG = Blocked Right Tube
April- Femara 2.5mg + Trigger + IUI = BFN
May- Femara 5mg = CX - No Response on Left = BFN
June- Femara 7.5mg + Trigger + IUI = BFN
August- Lap & Hysteroscopy = Blocked & Partially Blocked Tubes
Scar Tissue Removed, Left Tube Partially Open
September- Femara 5mg = CX - No Response on Left = BFN
October- 100mg Clomid + Trigger + TI = BFN
IVF # 1: Stims 11/30 ER 12/12/12! (10R, 8F, 2 Transferred, 6 Frosties!)
Beta #1- 176 c/p @ 4w4d
FET #1 February 26th
Lost 4 Frosties to Thaw, Transferred 2 = BFFN
IVF # 2 in May Stims Begin 5/10
ER 5/21

~~SAIF/PAIF Welcome~~

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12-20-2012 at 9:45 AM

daiseydood...

Joined on 04-28-2012

601 Posts

8,533 Points

daiseydooda is not online. Last active: 05-23-2013, 9:56 AM

My RE hasn't done additional testing, all she said was sometimes these things happen (extremely frustrating) So I decided to call my embryologist and talk to then about my quality of embryos in more detail. Which I've come to my own conclusion that my TE rating wasn't that good - it's the cells that have to do with implantation and placenta forming. That's the only thing that I can think of but who knows. Confused

TTC since 9/10 consult 1/12 All testing came back fine Diagnosed with Unexplained infertility All treatments OOP 3 medicated IUI's All BFN IVF - ER 11/14 24R, 15M, 13F ET 11/19, BETA 11/28 BFFN --Next step FET in Jan ET scheduled for 1/24. Beta #1 350 Beta #2 735. U/S Hell. miscarriage D&C at 9weeks. FET #2 ET 5/28 Beta 6/6. Everyone welcome

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12-20-2012 at 9:45 AM

megs3084

Joined on 12-26-2008

Chicago

2,033 Posts

28,319 Points

I hope so too, but I still like to have backup plans. Indifferent

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12-20-2012 at 9:56 AM

Rvnsgrl81

Joined on 12-30-2008

4,088 Posts

8,456 Points

Rvnsgrl81 is not online. Last active: 05-14-2013, 6:30 PM

***TICKER WARNING***

We were unexplained and had failed IUI's etc. When they went to begin testing for the IVF cycle they discovered a polyp not very big in my ute. They said it could or couldn't be the cause of my issues. Either way I had to have it removed by surgery before beginning IVF. It was a minor out patient procedure, similar to ER. We will never know for sure if that was the cause or not, they seem to think now it was, since both embryos we transferred implanted and stuck. We had tried for 2+ years before with meds, injections, IUI's, TI everything and no luck. I think it was a saline hysterogram or something that they discovered it through. Just a thought for you to ask about if you haven't already done so. I would have never thought that before either. GL and I hope your pee sticks are wrong!

P/SAIF Welcome
TTC Since 7/2010
TTC with charting, OPK's, etc since 8/2010
RE Appointment 9/9/11 = Unexplained IF. All tests for DH and I normal
2 Clomid + TI cycles = BFN
1 Clomid + IUI = BFN
1 Clomid + Injects + IUI = BFN
IVF #1 take 1 begins 8/6/12.
Surgery to remove uterine polyp 8/28/12 All clear!
Break due to Gallbladder Surgery 9/13/12.
IVF #1 Take 2 begins 9/7/12, Lupron begins 9/23/12
Stims begin 10/1/12 (150 Units of Bravelle and 75 Units of Menopur)
ER 10/15 12 eggs retreived, 12 mature and 8 fertilized on their own!
ET 10/20/12 Transferred 2 embies, 1 good and 1 fair extended blasts. 3 frosties waiting for us.
Beta #1 10/31 = 756 (11dp5dt)
Beta #2 11/2 = 1,310 (13dp5dt)
Beta #3 11/5 = 4,158 (16dp5dt)
First u/s 11/12 @ 6w = TWINS!! Both with heartbeats.
Next u/s 11/21 @ 7w3d = Both with heartbeats of 162 and 165.
Graduation Day 11/30 = Both babies looking perfect with heartbeats of 182 each.

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12-20-2012 at 10:02 AM

megs3084

Joined on 12-26-2008

Chicago

2,033 Posts

28,319 Points

Rvnsgrl81:
***TICKER WARNING***

We were unexplained and had failed IUI's etc. When they went to begin testing for the IVF cycle they discovered a polyp not very big in my ute. They said it could or couldn't be the cause of my issues. Either way I had to have it removed by surgery before beginning IVF. It was a minor out patient procedure, similar to ER. We will never know for sure if that was the cause or not, they seem to think now it was, since both embryos we transferred implanted and stuck. We had tried for 2+ years before with meds, injections, IUI's, TI everything and no luck. I think it was a saline hysterogram or something that they discovered it through. Just a thought for you to ask about if you haven't already done so. I would have never thought that before either. GL and I hope your pee sticks are wrong!

Thank you. I haven't had that test yet, but I'll add it to my list to ask him about. Were they able to see the polyp on a regular u/s?

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12-20-2012 at 10:12 AM

Juicy71

Joined on 11-18-2011

3,900 Posts

24,064 Points

Juicy71 is not online. Last active: 05-23-2013, 3:46 PM

After my failed IVF cycle, they didn't do any additional testing but for this cycle we added in an endometrial biopsy to see if that would help with implantation. FX that it does because it hurt like a b*tch!!

Keeping everything crossed for you that you get a positive beta though!!

Me: 41 DH: 37 - AMA, DOR
BFP 2.12.2012, c/p 2.17.2012
IUIs 1-3 = BFFN :(
IVF #1 - Sept 2012 = BFFN :(
IVF #2 - Dec 2012 = BFP!! EDD 9/4/2013
Beta #1 = 107, Beta #2 = 4,650!! U/S 1/15/2013
Everyone welcome!
Team Pink!!

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12-20-2012 at 10:20 AM

BellaLux

Joined on 07-24-2008

3,109 Posts

11,542 Points

BellaLux is not online. Last active: 05-22-2013, 2:21 PM

No advice, but crossing fingers and toes those sticks are wrong. Good luck tomorrow!

~TTC#1 Since July 2011~
Dx: 10/10 - Fibroids; 6/12 - Tubal Infertility
9/12 -IVF w/ICSI (Antagonist Protocol)=BFFN
Next: Feb 2013 -Myomectomy
S/PAIF Welcome

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12-20-2012 at 10:21 AM

megs3084

Joined on 12-26-2008

Chicago

2,033 Posts

28,319 Points

Juicy71:
After my failed IVF cycle, they didn't do any additional testing but for this cycle we added in an endometrial biopsy to see if that would help with implantation. FX that it does because it hurt like a b*tch!!

Keeping everything crossed for you that you get a positive beta though!!

I've heard they hurt. I was wondering about a biopsy as well. thanks for the input.

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12-20-2012 at 10:32 AM

Rvnsgrl81

Joined on 12-30-2008

4,088 Posts

8,456 Points

megs3084:
Rvnsgrl81:

***TICKER WARNING***

We were unexplained and had failed IUI's etc. When they went to begin testing for the IVF cycle they discovered a polyp not very big in my ute. They said it could or couldn't be the cause of my issues. Either way I had to have it removed by surgery before beginning IVF. It was a minor out patient procedure, similar to ER. We will never know for sure if that was the cause or not, they seem to think now it was, since both embryos we transferred implanted and stuck. We had tried for 2+ years before with meds, injections, IUI's, TI everything and no luck. I think it was a saline hysterogram or something that they discovered it through. Just a thought for you to ask about if you haven't already done so. I would have never thought that before either. GL and I hope your pee sticks are wrong!

Thank you. I haven't had that test yet, but I'll add it to my list to ask him about. Were they able to see the polyp on a regular u/s?

Apparently no. It was part of the testing to do the shared risk option of IVF, I am pretty sure they do it for any IVF cycle though. I know several people that have had it done, some have nothing some have a polyp or two. I am almost curious to see if that was the problem and do TI but we had wasted two much time and we were getting too close to the holidays to risk.

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12-20-2012 at 10:34 AM

jschwind22

Joined on 04-14-2011

3,934 Posts

42,363 Points

jschwind22 is not online. Last active: 05-23-2013, 8:11 AM

megs3084:
Rvnsgrl81:

***TICKER WARNING***

We were unexplained and had failed IUI's etc. When they went to begin testing for the IVF cycle they discovered a polyp not very big in my ute. They said it could or couldn't be the cause of my issues. Either way I had to have it removed by surgery before beginning IVF. It was a minor out patient procedure, similar to ER. We will never know for sure if that was the cause or not, they seem to think now it was, since both embryos we transferred implanted and stuck. We had tried for 2+ years before with meds, injections, IUI's, TI everything and no luck. I think it was a saline hysterogram or something that they discovered it through. Just a thought for you to ask about if you haven't already done so. I would have never thought that before either. GL and I hope your pee sticks are wrong!

Thank you. I haven't had that test yet, but I'll add it to my list to ask him about. Were they able to see the polyp on a regular u/s?

I'm glad you asked this! We are not unexplained (MFI), but there were no sperm issues that we know of with the IVF and all of my mature eggs fertilized normally. Before we do a FET, I want to be prepared to consider any other testing that we may need to do, especially on me, since 2 almost perfect embroys didn't take. I would second PP's recommendation for a SHG. This was standard prior to doing our IVF to check for polyps and other uterus issues that may not show up on an ultrasound. I'm interested to see if anyone else has any other suggestions! At what point is a lap usually recommended to check for endo?

May 3T Siggy Challenge- Dream Vacation- Italy
May TTGP Siggy Challenge- Superheros

TTC #1 since February 2011
Me: 29 (high NK cells diagnosed 3/5/13)
DH: 28 (MFI low morph and motility diagnosed 5/8/12).
RE is recommending IVF but we want to start with IUI. DH was unwilling to pursue treatment until 7/21/12.
Cycle #21- Injects + IUI #1=

Cycle #22- HSG 9/21/12 all clear=

Cycle #23- Injects + IUI#2=

Cycle #24- IVF #1- ER 12/6/12 (14R, 11M, 9F), ET 12/9/12 transferred 2 day 3 embies
Beta #1 10dp3dt=3 (-). Beta #2 12dp3dt=6.6 (+). Beta #3 39.1 (+)
Bleeding and low betas=very cautious

C/P 5W3D
Cycle #26- Diagnosed high NK cells 3/5/13. FET scheduled 3/20/13- CANCELLED- lining issues
Cycle #27- Starting Trental for 3 months for new FET protocol. Natural cycles until FET in August
PAIF/SAIF/ALL Welcome!

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12-20-2012 at 10:41 AM

megs3084

Joined on 12-26-2008

Chicago

2,033 Posts

28,319 Points

jschwind22:
megs3084:
Rvnsgrl81:

***TICKER WARNING***

We were unexplained and had failed IUI's etc. When they went to begin testing for the IVF cycle they discovered a polyp not very big in my ute. They said it could or couldn't be the cause of my issues. Either way I had to have it removed by surgery before beginning IVF. It was a minor out patient procedure, similar to ER. We will never know for sure if that was the cause or not, they seem to think now it was, since both embryos we transferred implanted and stuck. We had tried for 2+ years before with meds, injections, IUI's, TI everything and no luck. I think it was a saline hysterogram or something that they discovered it through. Just a thought for you to ask about if you haven't already done so. I would have never thought that before either. GL and I hope your pee sticks are wrong!

Thank you. I haven't had that test yet, but I'll add it to my list to ask him about. Were they able to see the polyp on a regular u/s?

I'm glad you asked this! We are not unexplained (MFI), but there were no sperm issues that we know of with the IVF and all of my mature eggs fertilized normally. Before we do a FET, I want to be prepared to consider any other testing that we may need to do, especially on me, since 2 almost perfect embroys didn't take. I would second PP's recommendation for a SHG. This was standard prior to doing our IVF to check for polyps and other uterus issues that may not show up on an ultrasound. I'm interested to see if anyone else has any other suggestions! At what point is a lap usually recommended to check for endo?

I had wondered about a lap as well. Not to be all Munchhausens about it, not like I WANT to have all these painful tests done, but I don't want to go through another cycle if theres something I could be doing to help first.

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12-20-2012 at 11:06 AM

sunflowers...

Joined on 05-12-2011

1,534 Posts

6,001 Points

sunflowers4AC is not online. Last active: 05-17-2013, 2:03 PM

We were unexplained but after having 23 mature eggs and only 1 fertilize naturally we realize that we need to ICSI right from the start instead of only using it as a rescue technique. Plus there was a tweak in the medications too. I think for us if 2 fails we will question additional testing.
I hope you can get some answers.

Married and TTC since November 2010 SA Normal, HSG Normal, B/W Normal = Unexplained IF
5 Failed IUI's Moving onto IVF, Stims Start 10/27, ER 11/5=27 eggs!, 23 mature, 1 Fertilized WTF?? Rescue ICSI on 12 and we had 3 more fertilize. Transfered 2 on 11/9. Beta on 11/23.
Everyone Welcome!
Chart Me For the blog of it!

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12-20-2012 at 11:08 AM

megs3084

Joined on 12-26-2008

Chicago

2,033 Posts

28,319 Points

sunflowers4AC:
We were unexplained but after having 23 mature eggs and only 1 fertilize naturally we realize that we need to ICSI right from the start instead of only using it as a rescue technique. Plus there was a tweak in the medications too. I think for us if 2 fails we will question additional testing. I hope you can get some answers.

Thank you. With IVF#1, we had to ICSI them all. With #2, we had enough to do an ICSI split (I was so happy about it!) but still nothing to freeze.

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12-20-2012 at 1:16 PM

J&D2007

Joined on 02-22-2007

1,074 Posts

19,831 Points

J&D2007 is not online. Last active: 04-28-2013, 8:12 AM

I had a rpl test panel. I know you thankfully haven't had losses, but sometimes that can pinpoint problems. We've had karyotyping done to check for any DNA issues. We are considering PGD testing with ivf#2 to rule out any DNA issues with the embryos.

Me: 35, DH: 36, ttc: 3+ years, dx: unknown
10/11: after 2 years, saw a RE, FSH 5.4
11/11: BFP! (surprise after thyroid med & normal hsg),
12/11: missed m/c after 7 week u/s,
1/12: D&C,
6/12 IUI #1: clomid, 5 mature follicles, excellent sperm,= BFN,
7/12: IUI #2: clomid, 3 mature follicles, excellent sperm= BFN,
8/12: IUi #3: clomid, 5 follicles, = BFP!, C/P
10/12 IVF #1: FSH 5.4, estradiol AFC: 14, long Lupron 150/bravelle75,5R/5M/4F, all 4 made it to 5dt, 1 blast and 1 8 cell transferred. No frosties. BFN
IVF #2: AFC 21, MD lupron 12/25, 225bravelle/150men, 4R/4M/3F, 5dt of 1 blast BFN
IVF #3: natural start antagon, starting 3/30, ER 4/11, 12R,11M,10F

[IMG]http://i248.photobucket.com/albums/gg174/pixydust3084/April_V2.jpg%5B/IMG]

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12-20-2012 at 4:27 PM

Gr8te

Joined on 08-18-2012

530 Posts

10,064 Points

Gr8te is not online. Last active: 05-22-2013, 7:23 PM

I'd ask about fragmented DNA.

~ Everyone Welcome ~
TTC: 05/2011 Me: 32, All Clear DH: 38 Dx: MFI Low Testosterone & 1% Morphology
IVF #1 w/ICSI & IMSI, 12/03/12: ER: 27R, 20M, 15F
4 blasts frozen (3BA 4BA 4BB 5BB) b/c of moderate OHSS
FET #1: 02/08/13 Transferred 3BA & 4BA | HPT 5dp5dt BFP!
10dp5dt Beta #1 - 810 | 12dp5dt Beta #2 - 1843

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12-20-2012 at 5:13 PM

kflynn81

Joined on 11-28-2009

Oak Lawn

1,842 Posts

28,245 Points

kflynn81 is not online. Last active: 05-20-2013, 9:08 PM

Juicy71:

After my failed IVF cycle, they didn't do any additional testing but for this cycle we added in an endometrial biopsy to see if that would help with implantation. FX that it does because it hurt like a b*tch!!

Keeping everything crossed for you that you get a positive beta though!!

Word.

Me(31): Possibly Adult Growth Hormone Deficiency caused by a mutation in my pituitary genes called PIT-1--Also, Factor V Leiden
DH (31): Borderline low morph, but not considered a problem
"Baby dancing" with no protection or BCP since July 2009
IF testing started March 2011
Endocrinology related tests from October 2011-February 2012
March 2012--Clomid --No response-Straight to injects!
April & May 2012-- IUI#1 & #2 = BFN
July 2012- IVF#1 cancelled
September 2012-IVF#1.2--BFN
November 2012- IVF #2 --BFN
January 2013- IVF #3-- BFFN
February 2013--Found a new RE but first back to the Endocrinologist for more diagnostic testing
Absolutely no idea when we can cycle again...looking into DE as well if IVF#4 fails again
PAIF/SAIF encouraged...give me some hope!!
For detailed cycle info. see right side of blog... Kate's IF Blog

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