This year DH and I decided not to send any presents to his brothers, they are the only people out of both of our families a total of 5 siblings and 2 sets of parents) not getting anything from us. The reason is that we have sent them birthday and Christmas presents and cards for years, and they have never once said thank you or even sent a card for a birthday or a holiday. This year they both made no effort to call DH on his birthday either. I could careless about getting a gift from them, but the fact that they don't even say thank you when we send them $50 gift cards for their birthdays or a thoughtful present for Christmas makes me angry.
One of his brothers lives in the same city as his sister, and I am secretly hoping he asks why she and her DH got a present (and a nice one at that) and they got nothing.