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12-29-2012 at 10:55 PM
kflynn81
Not Ranked
Joined on 11-28-2009
Oak Lawn
28,260 Points
kflynn81 is online. Last active: 05-23-2013, 8:55 PMBronze

Mast cells/Urticaria

Doctors always love me because I'm full of "fun" rare issues....one, of which sends doctors running into the office to see, is my urticaria pigmentosa. Its just a collection of external mast cells that release histamines and form "hives" under certain circumstances.

It might be a stretch but I wondered if anyone else has something similar going through IVF. My fear (today's fear) is that the mast cells are internal as well and perhaps lie in the uterine lining. I'm pretty sure, but haven't confirmed, that they're internal anyways, probably stomach. I came across some studies online regarding implantation failure and mast cells came up here and there.

Oh well...just one more thing to bug my RE about next week :)   She loves me, LOL :)


Anniversary
Me(31): Possibly Adult Growth Hormone Deficiency caused by a mutation in my pituitary genes called PIT-1--Also, Factor V Leiden
DH (31): Borderline low morph, but not considered a problem
"Baby dancing" with no protection or BCP since July 2009
IF testing started March 2011
Endocrinology related tests from October 2011-February 2012
March 2012--Clomid --No response-Straight to injects!
April & May 2012-- IUI#1 & #2 = BFN
July 2012- IVF#1 cancelled
September 2012-IVF#1.2--BFN
November 2012- IVF #2 --BFN
January 2013- IVF #3-- BFFN
February 2013--Found a new RE but first back to the Endocrinologist for more diagnostic testing
Absolutely no idea when we can cycle again...looking into DE as well if IVF#4 fails again
PAIF/SAIF encouraged...give me some hope!!
For detailed cycle info. see right side of blog... Kate's IF Blog
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12-30-2012 at 6:28 AM
jadwedd
Not Ranked
Joined on 04-29-2003
21,458 Points
jadwedd is not online. Last active: 05-22-2013, 8:50 PMBronze
I have no idea.  Just wanted to wish you good luck with that.

Married 12-12-04
TTC since 07
me-36 PCOS, Tubal Problems, and polyps removed 7-12
DH - 36 extremely handsome and no fertility problems
IUI 8-12 and 9-12 failed
IVF 12-21-2012 - 2 I think perfect no matter what the dr graded them (2B)embryos transferred Beta on 12-31-12 Positve - Beta is 21
Beta 2 1-2-13 - 31
Beta 3 1-4-13 - 53
Beta 4 1/9 - 212!
Ultrasound 1/10 - Nothing completely empty uterus Beta 1/14 - 743; Beta 1/17 - 1704 ultrasound shows nothing. Officially a miscarriage. 1/21 Beta 3900 Dr. says it ectopic. Ultrasound shows a miracle heartbeat right in the uterus where it belongs! Dr. says I can be cautiously optomistic!!! Hang in there baby!

 
12-30-2012 at 7:47 AM
hmz819
Not Ranked
Joined on 10-20-2009
Wilmington, NC
6,808 Points
hmz819 is not online. Last active: 05-23-2013, 8:43 PMBronze
I'd ask to get an immunology panel run. After our 2nd ivf failed we are looking into immune issues before we try 3. Good luck

TTC#1 since April 2011
IVF#1 July 2012 5R, 3 made it to blast, sET c/p
FET#1 Aug 2012 2 blasts transferred BFN
IVF#2 Oct 2012
16R/6M/6F/2-8 cell grade 1 transfer
Beta 1-237.9, Beta 2-566, Beta 3-8657
US 6w3d shows one baby w/ HB 115
US 7w1d no more heartbeat/ D&C 11/30/12 normal karyotype
IVF#3 Mar 2013
6R/4M/4F 1 compacting and 2-8 cell transfer
ectopic pg MTX given 3 month break from TTC
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12-30-2012 at 9:28 AM
megs3084
Not Ranked
Joined on 12-26-2008
Chicago
28,334 Points
megs3084 is online. Last active: 05-23-2013, 8:58 PMSilver
hmz819:
I'd ask to get an immunology panel run. After our 2nd ivf failed we are looking into immune issues before we try 3. Good luck

Im doing this too!


"Everything will be alright in the end. So if it's not alright, it is not yet the end."
"She wasn't bitter. She was sad, though. But it was a hopeful kind of sad. The kind of sad that just takes time." The Perks of Being a Wallflower

Me:28 DH:28 TTC since 1/11 Dx: unexplained IF/early DOR
Feb'12- Clomid/TI with CD3 &21 labs(normal)& SA-count 6mil/ml,morph/motil OK-BFN
April'12 Ultrasounds,HSG -clear, slight acurate uterus
5/14 IUI #1-50 mg clomid-post wash total motile count 19.3 prometrium 2dpiui= BFN
6/11-IUI #2-100 mg clomid & prometrium post wash count total motile 17.5 = BFN
7/6 IUI#3 with 100 mg clomid, estridiol, prometrium. post wash total motile count 23.3 = BFN
8/30IVF#1 BCPs, Follistim, Menopur,Ganerelix,Novarel.
ER 9/11-8R, 7M, 5F.
ET 9/14 2 embies transferred. 1 10cell Grade 4, 1 8cell Grade 4. No frosties. BFN
IVF#2 BCPs, Follistim, Menopur, Ganerelix, Novarel, Baby Aspirin
ER 12/5-16R, 12M, 8F!
ET 12/10 5dt! 1 fully expanded blast & 1 early blast. No frosties. BFN
2/13- Saline sono revealed a polyp. All additional labwork coming back normal. Genetic screen revealed DH has MTHFR deficiency & I am a carrier for it.
3/13 hysteroscopy & polypectomy
3/27 Began working with Reproductive Immunologist Dr. Kwak-Kim. Found High NK cells, High DHEAs, slight hypothyroidism, tendency toward blood clots (High PAI-1)Began synthroid & metformin 4/19.
Cycling in July

Here Comes the Sun Blog
PAIF/SAIF welcome! 
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