YES. There IS a difference. My BIGGEST regret in preparing for our LO was not buying a full sized swing. We bought a $65 portable or space saver swing and have spent well over $100 batteries for the d@mned thing.
If I could go back I would buy a full sized swing without even batting an eye at the price. We've spent WAY too much replacing batteries in our stupid portable one.
ETA- We have a Fisher Price Love U Zoo swing.