I started with just B6 (i only do 25mg 3x a day), and later added Unisom. I started with a half tablet (because the first time I took it, I did a full tablet, and I was a groggy zombie the whole next day), but after a few weeks, I moved up to 3/4 and then a whole tablet (i might have been able to go straight to a whole, but did the 3/4 for about 4 days first, since I'd had the groggy issues, so I could start a full over a weekend).
I moved up to the full tablet partially because I am also taking Unisom for early-morning insomnia (waking at 3-4 am) and the 1/2 had stopped working for that.
I am still having morning (all day) sickness, but it is tolerable most of the time, even though most days I can't eat all that much. Sometimes i have moments, usually early evening, when I can eat almost normally, but I'm still fairly nauseous a lot. I'm scared what it would be like if I wasn't taking the B6 and Unisom!