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01-15-2013 at 8:07 PM
Amyou06
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Joined on 10-24-2010
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Amyou06 is not online. Last active: 02-17-2013, 12:53 PMNewbie

Question about follicle growth on IVF....

So I'm obsessing a little here. Yesterday was my first monitoring appointment and I have 8 total follicles, 3, that were 9-10 and 5 that were 4-6. We increased my dose of folistim from 150 to 225 menapur stays the same at 75...My question is this...If we speed up the growth of the small ones, in theory the big ones should also get a boost...so what if those 3 get to the max size way before the rest? Will RE give time for the rest to catch up? I just read someone who said they had a similar situation and the bigger ones got maxed out early so she was forced to trigger....I want them all to have a chance to get nice and mature...just looking for some insight.
TTC since 11/11. 10 months natural= 10 BFN 8/12 First appt with RE 4 semen anaylsis later 1.9 million count, 21% motility and very poor morphology Me- bloodwork, 2 ultrasounds, HSG exam =I'm fine 3 months of testosterone treatments = 3 more BFN DH bkoodwork after 3 months treatment= no change RE says we can continue with hormone treatment for MIF, But says it could be year or more to see results that would even make us IUI candidates RE says we can try IUI but doesn't expect the results to be good based on severe MIF. 12/12 decide to move forward with IVF Started IVF Cycle #1 1/11/13 
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01-15-2013 at 10:36 PM
chucktgirl
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Joined on 06-01-2006
Michigan
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chucktgirl is not online. Last active: 04-18-2013, 4:43 PMBronze
I am going through similar right now. I am on Stim day 9, and mine range from 10 - 20 (as of Mon). My RE considered triggering me early, but I only had 4 ready. Instead, he's having me stim two more days in hopes of letting the others grow. If the big ones get too big, then I think they just let them go. They will be lost follicles. It's a gamble. I'm hoping for the best. I will find out in about six hours if it worked for me. Fingers crossed!

My (old) BLOG: www.ivfbabyquest.wordpress.com
TTC since Jan 2010 with OPKs. Me: 41, Hypothyroidism, hetero MTHFR C677T, hetero Factor V Leiden (no previous clots) Dx: DOR due to AMA. Rx: 100mg Levothyroxin, FaBB tab, Spring Valley Prenatal Vitamins, Vitamin D. Hubby: 34, Hyperthyroidism, Fragile X carrier, Great swimmers!
Natural PG 9/27/11; MC at 8wks. Used Cytotec to expel: 1/20/12 (unpleasant)
First RE visit: 8/8/12, Saline Sonogram: 8/28/12(4cm unknown mass in upper left of uterus) 2nd Saline Sonogram: 10/2/12 (mass disappeared!) IVF injection class: 10/11/12
IVF #1: 10/17/12 Baseline: FSH- 9.4, E2- 24, LH- 3.7, Progesterone- 0.3. 6 follicles in my right ovary & 9 in my left. Rx: 150 Bravelle & 150 Menopur SQ in AM. 10/21/12: Add Ganirelix SQ in PM. 10/26/12: hCG Trigger IM. ER 10/28/12: 13R, 7M, 6F. 5 Made it to PGS. ET 11/2/12: CANCELED. PGS: All 5 have "severe abnormalities." Devastated. Begged RE for back-to-back IVFs; Started Provera 11/2/12. AF said FU and came anyway, destroying any chance for a Dec IVF. Maxed out lifetime IF meds insurance. I can barely breathe, waiting to get through this process, hoping for my take-home-baby.
IVF #2: 1/7/13 Baseline: FSH- 8.8, 4 follicles in my right ovary & 6 in my left. Rx: 150 Bravelle & 150 Menopur SQ in PM. 1/11/13: Add Ganirelix SQ in AM. 1/16/13: hCG Trigger IM. ER 1/18/13: 9R, 5M, 5F. 2 Made it to PGS. ET 1/23/13: CANCELED. PGS: All embryos have "multiple severe abnormalities." RE recommends we stop trying and focus on living childless, due to the repeated extremely poor quality of my eggs. I don't even know what to do with that.
IVF #3- NEW RE! 100% OOP: 3/1/13 Baseline: FSH- 9.6, E2- 61, Progesterone- 0.94, 3 follicles in my right ovary & 4 in my left. Rx: 150 Bravelle & 150 Menopur SQ in PM. 3/7/13: Add Ganirelix SQ in AM. hCG Trigger 3/9/13 SQ. 3/11/13 ER: 6R, 2M, 2F. Day 3: one 8 cell, grade 0. 3/16/13 Five day ET: one early blast, grade Fair. 3/24/13 Started period a day before beta. BFN.
IVF #4 (FINAL) (Added acupuncture to this cycle.): 3/25/13 WTF & Baseline: FSH-11.8, E2- 56, Progesterone- 0.84 3/26/13 Start stims. 3/30/13 u/s: 5 follicles in my right ovary & 4 in my left. Rx: 225 Bravelle & 225 Menopur SQ in PM. 3/31/13 Add Ganirelix SQ in AM. hCG Trigger 4/3/13 SQ. 4/5/13 ER: 5R, 3M, 3F naturally. Day 3: two 8 cell, grade 0, one 8 cell, grade 2 (Scale 0-best to 3-worst). 4/10/13 Five day ET: two blastocysts (the 3rd stopped growing.) 4/18/13 Beta: 2.5 BFFN.
No DE or adoption for us, FIRM.
That’s it for us. I am beyond devastated and have no idea how to proceed from here. My life has been forever altered by this experience. Best wishes to all in their journeys! 
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01-16-2013 at 5:36 AM
jadwedd
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Joined on 04-29-2003
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jadwedd is not online. Last active: 05-25-2013, 8:27 AMBronze
I think that this is one of those situations where you just have to trust the dr and that they he/she knows what they are doing.  They will do whatever is best for you.  I always figure that they want this to work just as much as I do because they have to publish their success rates.  Good luck!
Married 12-12-04
TTC since 07
me-36 PCOS, Tubal Problems, and polyps removed 7-12
DH - 36 extremely handsome and no fertility problems
IUI 8-12 and 9-12 failed
IVF 12-21-2012 - 2 I think perfect no matter what the dr graded them (2B)embryos transferred Beta on 12-31-12 Positve - Beta is 21
Beta 2 1-2-13 - 31
Beta 3 1-4-13 - 53
Beta 4 1/9 - 212!
Ultrasound 1/10 - Nothing completely empty uterus Beta 1/14 - 743; Beta 1/17 - 1704 ultrasound shows nothing. Officially a miscarriage. 1/21 Beta 3900 Dr. says it ectopic. Ultrasound shows a miracle heartbeat right in the uterus where it belongs! Dr. says I can be cautiously optomistic!!! Hang in there baby!

 
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01-16-2013 at 8:35 AM
kflynn81
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Joined on 11-28-2009
Oak Lawn
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kflynn81 is not online. Last active: 05-25-2013, 6:52 PMBronze

You'll probably know more about the growth of the follicles as a whole at your next appointment. That first appt. is like a jumping off point to see how you're responding to meds...since they bumped you up you just needed a little extra boost. My first cycle started at the same doses you were on but wound up being 300iu of Follistim and 150iu Menopur to get me where I needed to go.

Good luck, when is your next appt.??
Anniversary
Me(31): Possibly Adult Growth Hormone Deficiency caused by a mutation in my pituitary genes called PIT-1--Also, Factor V Leiden
DH (31): Borderline low morph, but not considered a problem
"Baby dancing" with no protection or BCP since July 2009
IF testing started March 2011
Endocrinology related tests from October 2011-February 2012
March 2012--Clomid --No response-Straight to injects!
April & May 2012-- IUI#1 & #2 = BFN
July 2012- IVF#1 cancelled
September 2012-IVF#1.2--BFN
November 2012- IVF #2 --BFN
January 2013- IVF #3-- BFFN
February 2013--Found a new RE but first back to the Endocrinologist for more diagnostic testing
Absolutely no idea when we can cycle again...looking into DE as well if IVF#4 fails again
PAIF/SAIF encouraged...give me some hope!!
For detailed cycle info. see right side of blog... Kate's IF Blog
Image and video hosting by TinyPic
 
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01-16-2013 at 8:41 AM
new+tothis
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new+tothis is not online. Last active: 05-25-2013, 10:56 PMBronze
My RE can go either way - sometimes they let a couple get too big to let smaller ones catch up and sometimes they trigger before the smaller ones catch up. I'm not sure how they decide but it's all about what they think will give the best results. I had one follie that was way too big - like 28. It was always the leader and by letting it get too big I think they were hoping for 4 smaller ones to catch up. I'm not positive but I'm pretty sure that's how it happened too.

TTC #1 for Dh, #2 for me. HSG clear. Low AMH and endo. Multiple Clomid w/TI cycles - all BFNs. 2 IUIs with Clomid and 1 with Femara - more BFNs. IVF#1 25R, 15M, 15F. 5DT of two perfect 4AA blasts! Positive HPT at 5dp5dt. Beta #1 6dp5dt - 72. Beta #2 8dp5dt - 285. Beta #3 10dp5dt - 793. Both babies have strong beautiful heartbeats! Baby B miscarried at 7 weeks. Baby A is holding on through miscarrying her twin, sub-chorionic hematoma, and complete placenta previa. Stick, baby, stick!

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01-16-2013 at 9:13 AM
Amyou06
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Joined on 10-24-2010
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Amyou06 is not online. Last active: 02-17-2013, 12:53 PMNewbie
Hey Ladies, thanks for the feedback. I had my 2nd monitoring appointment today. I have my third on Friday. I started my ganirelex this morning at the RE's office, and we're looking for  ER on Sunday or Monday. As far as follicles, things are looking better. I had about 12 total. still 3 leading the charge at 14-15 and I have a few 10, 11, and 12's they are hoping will catch up by the time I go in. Which is completely plausible since we have another 4-5 days before the ER. So my coordnator said by looking at everything now, she is thinking come retrival, we could get around 8 eggs. Which would make me feel loads better than the 3 I was originally thinking based on my first appointment. So I'm hoping by Friday even some of the ones at 5-6 might catch up in 4-5 days. I think they could! Staying postive!  :)
TTC since 11/11. 10 months natural= 10 BFN 8/12 First appt with RE 4 semen anaylsis later 1.9 million count, 21% motility and very poor morphology Me- bloodwork, 2 ultrasounds, HSG exam =I'm fine 3 months of testosterone treatments = 3 more BFN DH bkoodwork after 3 months treatment= no change RE says we can continue with hormone treatment for MIF, But says it could be year or more to see results that would even make us IUI candidates RE says we can try IUI but doesn't expect the results to be good based on severe MIF. 12/12 decide to move forward with IVF Started IVF Cycle #1 1/11/13 
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01-16-2013 at 12:48 PM
new+tothis
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new+tothis is not online. Last active: 05-25-2013, 10:56 PMBronze
That's great news! I had a monitoring appt the day I started my Ganirelix and they estimated I would have 15 mature eggs.... and they were spot on! Hopefully the same is true for you and you'll get 8 awesome eggs!

TTC #1 for Dh, #2 for me. HSG clear. Low AMH and endo. Multiple Clomid w/TI cycles - all BFNs. 2 IUIs with Clomid and 1 with Femara - more BFNs. IVF#1 25R, 15M, 15F. 5DT of two perfect 4AA blasts! Positive HPT at 5dp5dt. Beta #1 6dp5dt - 72. Beta #2 8dp5dt - 285. Beta #3 10dp5dt - 793. Both babies have strong beautiful heartbeats! Baby B miscarried at 7 weeks. Baby A is holding on through miscarrying her twin, sub-chorionic hematoma, and complete placenta previa. Stick, baby, stick!

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01-16-2013 at 6:55 PM
Amyou06
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Amyou06 is not online. Last active: 02-17-2013, 12:53 PMNewbie
Thanks and best of luck to you too!!
TTC since 11/11. 10 months natural= 10 BFN 8/12 First appt with RE 4 semen anaylsis later 1.9 million count, 21% motility and very poor morphology Me- bloodwork, 2 ultrasounds, HSG exam =I'm fine 3 months of testosterone treatments = 3 more BFN DH bkoodwork after 3 months treatment= no change RE says we can continue with hormone treatment for MIF, But says it could be year or more to see results that would even make us IUI candidates RE says we can try IUI but doesn't expect the results to be good based on severe MIF. 12/12 decide to move forward with IVF Started IVF Cycle #1 1/11/13 
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