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01-15-2013 at 8:47 PM
Mattysgirl...
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Joined on 04-15-2004
Colorado
169 Points
Mattysgirl04 is not online. Last active: 03-30-2013, 4:14 PMNewbie

Pgd testing

Hi ladies,

I was on this board for several years when we were trying to get pregnant the first time and now back  for round two of IVF.  Because of my age (37) and egg quality my RE is recommending doing PGD testing.  Just curious if any of you have had this done and if you felt it was worth it.  I am on the fence but it increases or chances of getting pregnant by 75%.

Thanks for your thoughts.

 



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01-15-2013 at 8:52 PM
Mattysgirl...
Not Ranked
Joined on 04-15-2004
Colorado
169 Points
Mattysgirl04 is not online. Last active: 03-30-2013, 4:14 PMNewbie
Oh my, baby pic here, I am so sorry.  If anyone can guide me on how to remove I can do it.  I know how hard it is to see that when going through stupid IF.  Sorry in advance.


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01-15-2013 at 9:09 PM
cupcake201
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Joined on 11-16-2011
4,968 Points
cupcake201 is not online. Last active: 05-19-2013, 4:36 PMBronze
We are doing PGD, but due to a chromosomal issue, not because of age. I think it's a personal decision and you should do whatever your and DH are most comfortable with. PGD will tack on about an extra 4k to your IVF costs which is also something to think about. I know there are women on this board who are your age and doing IVF without PGD, and also women on PAIF who didn't use PGD. I know I am sort of babbling and not answering your question...but I hope that is somewhat helpful!

ETA I am mobile bumping and can't see if you have your history in your siggy, but if I were you I'd also speak with my RE about if there are concerns about your egg quality aside from just your age.

Image and video hosting by TinyPic

TTC#1 since 4/11 : m/c in 9/11 & 11/11
DH dx with Balanced Translocation 5/12
10/12 IVF#1-7R, 3M, 3F- No transfer - Froze 2.
IVF#2 1/13 - 11R, 10M, 6F, no transfer
IVF#3 4/13 - 8R, 6M, 6F, 1 passed PGD and was transfered 5/2/13
S/PAIF Welcome
 
01-15-2013 at 10:46 PM
chucktgirl
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Joined on 06-01-2006
Michigan
19,963 Points
chucktgirl is not online. Last active: 04-18-2013, 4:43 PMBronze
I am 41, poor egg quality. IVF we did PGD/PGS (I'm not clear on which). Five of nine fertilized embryos made it through. Unfortunately all five showed "severe genetic abnormalities" so we did not have a Transfer. (That sucked big time.) Before we started our 2nd cycle, my RE recommended that we do NOT do PGS (it requires a 5 day transfer) and instead transfer whatever embryos I may have on day 3. My husband and I decided against that. This is probably our last chance at at IVF (out of money) and we want the best chance for a healthy pregnancy. There are huge negatives, however. 1. It costs us $3250 no matter if we have one embryo or ten. 2. Not all embryos thrive outside of the uterus, so waiting 5 days might kill off some that might have otherwise survived inside my uterus. 3. Sometimes the removing of a cell for testing can damage the embryo, rendering it useless. 4. The test has a 5 - 10% failure rate, which means that it's possible you'll get an abnormal reading when really the embryo is fine. It's a huge double-edged sword. I think if we had more TIME we wouldn't do the testing. But we don't. I don't have enough months left to go through 3 months of pregnancy only to have it fail, then have a D&C, then recover, and by the end of all that, it's six months later. I am simply out of time. So, our decision is based on that. Good luck with your decision.


My (old) BLOG: www.ivfbabyquest.wordpress.com
TTC since Jan 2010 with OPKs. Me: 41, Hypothyroidism, hetero MTHFR C677T, hetero Factor V Leiden (no previous clots) Dx: DOR due to AMA. Rx: 100mg Levothyroxin, FaBB tab, Spring Valley Prenatal Vitamins, Vitamin D. Hubby: 34, Hyperthyroidism, Fragile X carrier, Great swimmers!
Natural PG 9/27/11; MC at 8wks. Used Cytotec to expel: 1/20/12 (unpleasant)
First RE visit: 8/8/12, Saline Sonogram: 8/28/12(4cm unknown mass in upper left of uterus) 2nd Saline Sonogram: 10/2/12 (mass disappeared!) IVF injection class: 10/11/12
IVF #1: 10/17/12 Baseline: FSH- 9.4, E2- 24, LH- 3.7, Progesterone- 0.3. 6 follicles in my right ovary & 9 in my left. Rx: 150 Bravelle & 150 Menopur SQ in AM. 10/21/12: Add Ganirelix SQ in PM. 10/26/12: hCG Trigger IM. ER 10/28/12: 13R, 7M, 6F. 5 Made it to PGS. ET 11/2/12: CANCELED. PGS: All 5 have "severe abnormalities." Devastated. Begged RE for back-to-back IVFs; Started Provera 11/2/12. AF said FU and came anyway, destroying any chance for a Dec IVF. Maxed out lifetime IF meds insurance. I can barely breathe, waiting to get through this process, hoping for my take-home-baby.
IVF #2: 1/7/13 Baseline: FSH- 8.8, 4 follicles in my right ovary & 6 in my left. Rx: 150 Bravelle & 150 Menopur SQ in PM. 1/11/13: Add Ganirelix SQ in AM. 1/16/13: hCG Trigger IM. ER 1/18/13: 9R, 5M, 5F. 2 Made it to PGS. ET 1/23/13: CANCELED. PGS: All embryos have "multiple severe abnormalities." RE recommends we stop trying and focus on living childless, due to the repeated extremely poor quality of my eggs. I don't even know what to do with that.
IVF #3- NEW RE! 100% OOP: 3/1/13 Baseline: FSH- 9.6, E2- 61, Progesterone- 0.94, 3 follicles in my right ovary & 4 in my left. Rx: 150 Bravelle & 150 Menopur SQ in PM. 3/7/13: Add Ganirelix SQ in AM. hCG Trigger 3/9/13 SQ. 3/11/13 ER: 6R, 2M, 2F. Day 3: one 8 cell, grade 0. 3/16/13 Five day ET: one early blast, grade Fair. 3/24/13 Started period a day before beta. BFN.
IVF #4 (FINAL) (Added acupuncture to this cycle.): 3/25/13 WTF & Baseline: FSH-11.8, E2- 56, Progesterone- 0.84 3/26/13 Start stims. 3/30/13 u/s: 5 follicles in my right ovary & 4 in my left. Rx: 225 Bravelle & 225 Menopur SQ in PM. 3/31/13 Add Ganirelix SQ in AM. hCG Trigger 4/3/13 SQ. 4/5/13 ER: 5R, 3M, 3F naturally. Day 3: two 8 cell, grade 0, one 8 cell, grade 2 (Scale 0-best to 3-worst). 4/10/13 Five day ET: two blastocysts (the 3rd stopped growing.) 4/18/13 Beta: 2.5 BFFN.
No DE or adoption for us, FIRM.
That’s it for us. I am beyond devastated and have no idea how to proceed from here. My life has been forever altered by this experience. Best wishes to all in their journeys! 
01-16-2013 at 5:45 AM
J&D2007
Not Ranked
Joined on 02-22-2007
19,831 Points
J&D2007 is not online. Last active: 04-28-2013, 8:12 AMBronze
Hi and welcome. We've been through the PGS debate at my house for months and its very hard to make a decision for us. If I am not mistaken, PGD is used where they make a specific probe for a specific defect they are looking for.  Say, you or DH has a chromosomal issue you could pass on, then they would make a probe for that and test each embryo for it. PGS I believe is a screening test for the embryos, basically making sure they have the correct number of chromosomes, no extra pairs, no deletions. We would have had PGS. My RE strongly recommended it but we chose not to thus far. And the only reason is that we have gotten only 4 eggs on retrieval. To me, it's pretty pointless to spend the extra money if only 1 egg is going to make it to blast anyway...it's not like we're 'weeding out' the bad ones.. Not sure how much research you've done, but my DH came across one of the larger studies that actually shows that pregnancy rate is no better with PGS than without.. Maybe it was on advanced fertility website? I don't remember. I'm not trying to talk you out if it, I would do it for sure if I had more embryos to deal with!


Me: 35, DH: 36, ttc: 3+ years, dx: unknown
10/11: after 2 years, saw a RE, FSH 5.4
11/11: BFP! (surprise after thyroid med & normal hsg),
12/11: missed m/c after 7 week u/s,
1/12: D&C,
6/12 IUI #1: clomid, 5 mature follicles, excellent sperm,= BFN,
7/12: IUI #2: clomid, 3 mature follicles, excellent sperm= BFN,
8/12: IUi #3: clomid, 5 follicles, = BFP!, C/P
10/12 IVF #1: FSH 5.4, estradiol AFC: 14, long Lupron 150/bravelle75,5R/5M/4F, all 4 made it to 5dt, 1 blast and 1 8 cell transferred. No frosties. BFN
IVF #2: AFC 21, MD lupron 12/25, 225bravelle/150men, 4R/4M/3F, 5dt of 1 blast BFN
IVF #3: natural start antagon, starting 3/30, ER 4/11, 12R,11M,10F
.
[IMG]http://i248.photobucket.com/albums/gg174/pixydust3084/April_V2.jpg%5B/IMG] 
01-16-2013 at 9:15 AM
Rescuemom3...
Not Ranked
Joined on 11-09-2012
192 Points
Rescuemom34 is not online. Last active: 05-20-2013, 2:29 PMNewbie
Im going through the process of PGD right now- but mine is for a diagnosed transloction that I carry.  As others have mentioned it really is a personal decision, and honestly if I did not know for sure that I had a genetic issue I probably would not do it as I am constantly terrified that my embryos will not even make it to day 5 for testing.  That being said, as mentioned in my siggy we did choose to skip the PGD with our last IVF and m/c'd at almost 12 weeks.  That was horrific and for DH and myself we have decided that after going through that we will not put back any embryos that have not been tested.  There are different ways to do the PGD, not all involve a probe (the one I am doing is called micro array).  You may want to speak with a genetics counselor at whatever lab yoru RE uses for PGD and they may be able to give you more detailed info to help you decide. Sorry this was so long, but I hope it helps at least a little!  Good luck!

TTC since 9/2008- 1 year of working with OB using Clomid(unmonitored) resulted in 1 BFP and M/C at 5w6d. Switched and new OB sent me straight to RE. Diagnosed as significant PCOS as well as balanced translocation (me, 10:12) IVF w/ICSI and PGD #1 March 2010, transferred 2 blasts- BFFN, IVF wICSI and PGD #2 June/July 2010 tested and froze on Day 5- only 1 to transfer, FET- BFFN, IVF w/ICSI PGD 3.1- no balanced embies to transfer :-( emotional/physical break- switched to IUI did 6, got a BFP on #2, confirmed c/p IVF #3 w/ICSI, chose to skip PGD- ER was in October 2011- ended up with Massive internal bleeding from both ovaries, admitted to ICU for transfusions (blood and platelets)- freeze all on day 3. I made a full recovery- did FET of 4, day 3 embies (no PGD) BFP! 1 beautiful HB- last live U/S at 9w 4d, at NT discovered no HB, fetus likely stopped growing around 11 w, D&E at 12w, pathology confirmed that the fetus had imbalanced translocation. 6 cycles of trying on own with Ov Induction- 1 BFP and confirmed c/p Oct 2012 IVF #4 Feb 2013?  
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