***TICKER WARNING, PAIF/SAIF POSTER***
I can't speak to PGD/PGS, but can tell you there are other options besides amnio once you are pregnant. For my first pregnancy, we opted to do the quad screen, which is an ultrasound (NT Scan) that checks the folds in the baby's neck between 11 and 14 weeks, along with some blood work done at a couple points in time, to determine the odds (can't tell you specifics) of chromosomal abnormalities. It is completely non-invasive, so no risk to the baby.
There is also CVS (chorionic villus sampling), which is slightly more invasive, and has a low chance of miscarriage (1%). Here is a little info: CVS. And of course, there is also the amnio.
DH and I decided to do the quad screen,and if we felt there was a major risk, we would move forward with either CVS or Amnio, but luckily we felt comfortable with our results and didn't pursue additional testing (and none was recommended).
During that pregnancy, a new test was just starting to be used, called MaterniT21: MaterniT21 This one is supposed to tell you yes/no whether there are chromosomal abnormalities, and added bonus is that it can tell you the sex of your child. I believe it can be done any time after 10 weeks.
This time, my RE recommended both the quad screen (or at least the NT scan) and the Materni21. I was already scheduled for the quad screen and called the office back to add the T21, but the doctor said I had to do one or the other, because the blood work overlaps. She said we can discuss it when I go in for my appt in a week and a half. I am going to push for the NT scan and T21 test, but will see what the doctor recommends.
Sorry so long, but hopefully there is some useful information in here for you!